{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Major M"],"funding":["Dutch Research Council (NWO)","Nationaal Regieorgaan Praktijkgericht Onderzoek SIA"],"pagination":["e0284097"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10101425"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(4)"],"pubmed_abstract":["<h4>Background</h4>Mechanical ventilation affects the respiratory muscles, but little is known about long-term recovery of respiratory muscle weakness (RMW) and potential associations with physical functioning in survivors of critical illness. The aim of this study was to investigate the course of recovery of RMW and its association with functional outcomes in patients who received mechanical ventilation.<h4>Methods</h4>We conducted a prospective cohort study with 6-month follow-up among survivors of critical illness who received ≥ 48 hours of invasive mechanical ventilation. Primary outcomes, measured at 3 timepoints, were maximal inspiratory and expiratory pressures (MIP/MEP). Secondary outcomes were functional exercise capacity (FEC) and handgrip strength (HGS). Longitudinal changes in "],"journal":["PloS one"],"pubmed_title":["Course of recovery of respiratory muscle strength and its associations with exercise capacity and handgrip strength: A prospective cohort study among survivors of critical illness."],"pmcid":["PMC10101425"],"funding_grant_id":["023.007.006","RAAK.PUB04.037"],"pubmed_authors":["van der Schaaf M","Dettling-Ihnenfeldt D","Major M","Ramaekers S","van Egmond M","Engelbert R"],"additional_accession":[]},"is_claimable":false,"name":"Course of recovery of respiratory muscle strength and its associations with exercise capacity and handgrip strength: A prospective cohort study among survivors of critical illness.","description":"<h4>Background</h4>Mechanical ventilation affects the respiratory muscles, but little is known about long-term recovery of respiratory muscle weakness (RMW) and potential associations with physical functioning in survivors of critical illness. The aim of this study was to investigate the course of recovery of RMW and its association with functional outcomes in patients who received mechanical ventilation.<h4>Methods</h4>We conducted a prospective cohort study with 6-month follow-up among survivors of critical illness who received ≥ 48 hours of invasive mechanical ventilation. Primary outcomes, measured at 3 timepoints, were maximal inspiratory and expiratory pressures (MIP/MEP). Secondary outcomes were functional exercise capacity (FEC) and handgrip strength (HGS). Longitudinal changes in ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-22T13:42:59.95Z","creation":"2025-04-06T00:43:37.183Z"},"accession":"S-EPMC10101425","cross_references":{"pubmed":["37053226"],"doi":["10.1371/journal.pone.0284097"]}}