{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Oakey H"],"funding":["National Health and Medical Research Council of Australia","JDRF International Postdoctoral Fellowships","LCH","Leona M. and Harry B. Helmsley Charitable Trust","JDRF Australia","NHMRC Practitioner fellowship","MEC","NHMRC Leadership Investigator Grant","JDRF Australia Pilot and Innovation Award scheme","JDRF International Strategic Research Award scheme","Medical Research Future Fund","Diabetes SA. KWK and AH"],"pagination":["2198255"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10101668"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["55(1)"],"pubmed_abstract":["<b>Background:</b> The Environmental Determinants of Islet Autoimmunity (ENDIA) pregnancy-birth cohort investigates the developmental origins of type 1 diabetes (T1D), with recruitment between 2013 and 2019. ENDIA is the first study in the world with comprehensive data and biospecimen collection during pregnancy, at birth and through childhood from at-risk children who have a first-degree relative with T1D. Environmental exposures are thought to drive the progression to clinical T1D, with pancreatic islet autoimmunity (IA) developing in genetically susceptible individuals. The exposures and key molecular mechanisms driving this progression are unknown. Persistent IA is the primary outcome of ENDIA; defined as a positive antibody for at least one of IAA, GAD, ZnT8 or IA2 on two consecutive "],"journal":["Annals of medicine"],"pubmed_title":["Protocol for a nested case-control study design for omics investigations in the Environmental Determinants of Islet Autoimmunity cohort."],"pmcid":["PMC10101668"],"funding_grant_id":["JDRF 2-SRA-2022-1100-M-B","APP1136735","APP1173945","G-2103-05117","3-SRA-2020-966-M-N","JDRF 3-PDF-2020-940-A-N","3-SRA-2019-730-S-B","2-SRA-2022-1094-M-B","17-2013-526","3-SRA-2019-899-M-N","2-SRA-2021-1083-M-B","APP1078106","3-PDF-2020-939-A-N","G-2112-04908","JDRF 3-SRA-2017-417-A-N","2-SRA-2021-1085-M-B"],"pubmed_authors":["Morahan G","Le Cao KA","Rawlinson WD","Ashwood P","Kim KW","Mallitt KA","Wentworth JM","Giles LC","Sinnott RO","Knight EJ","McGorm K","Craig ME","Davis EA","Penno MAS","Thomson RL","Barry SC","Harrison LC","Couper JJ","Colman PG","Oakey H","Haynes A","Soldatos G","ENDIA Study Group","Brown JD","Hamilton-Williams EE"],"additional_accession":[]},"is_claimable":false,"name":"Protocol for a nested case-control study design for omics investigations in the Environmental Determinants of Islet Autoimmunity cohort.","description":"<b>Background:</b> The Environmental Determinants of Islet Autoimmunity (ENDIA) pregnancy-birth cohort investigates the developmental origins of type 1 diabetes (T1D), with recruitment between 2013 and 2019. ENDIA is the first study in the world with comprehensive data and biospecimen collection during pregnancy, at birth and through childhood from at-risk children who have a first-degree relative with T1D. Environmental exposures are thought to drive the progression to clinical T1D, with pancreatic islet autoimmunity (IA) developing in genetically susceptible individuals. The exposures and key molecular mechanisms driving this progression are unknown. Persistent IA is the primary outcome of ENDIA; defined as a positive antibody for at least one of IAA, GAD, ZnT8 or IA2 on two consecutive ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-05T14:51:49.153Z","creation":"2025-04-05T14:51:49.153Z"},"accession":"S-EPMC10101668","cross_references":{"pubmed":["37043275"],"doi":["10.1080/07853890.2023.2198255"]}}