{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ioannidis LJ"],"funding":["Ministry of Research and Technology of Indonesia","National Health and Medical Research Council","Australian Academy of Science"],"pagination":["24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10103532"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(1)"],"pubmed_abstract":["<h4>Background</h4>Typical symptoms of uncomplicated dengue fever (DF) include headache, muscle pains, rash, cough, and vomiting. A proportion of cases progress to severe dengue hemorrhagic fever (DHF), associated with increased vascular permeability, thrombocytopenia, and hemorrhages. Progression to severe dengue is difficult to diagnose at the onset of fever, which complicates patient triage, posing a socio-economic burden on health systems.<h4>Methods</h4>To identify parameters associated with protection and susceptibility to DHF, we pursued a systems immunology approach integrating plasma chemokine profiling, high-dimensional mass cytometry and peripheral blood mononuclear cell (PBMC) transcriptomic analysis at the onset of fever in a prospective study conducted in Indonesia.<h4>Result"],"journal":["Journal of biomedical science"],"pubmed_title":["Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever."],"pmcid":["PMC10103532"],"funding_grant_id":["Regional Collaboration Grant","Ministry of Research and Technology of Indonesia","Independent Medical Research Institutes Infrastructure Support Scheme","200466"],"pubmed_authors":["Liao Y","Ioannidis LJ","Suwarto S","Hansen DS","Studniberg SI","Shi W","Eriksson EM","Denis D","Garnham AL","Sasmono RT"],"additional_accession":[]},"is_claimable":false,"name":"Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever.","description":"<h4>Background</h4>Typical symptoms of uncomplicated dengue fever (DF) include headache, muscle pains, rash, cough, and vomiting. A proportion of cases progress to severe dengue hemorrhagic fever (DHF), associated with increased vascular permeability, thrombocytopenia, and hemorrhages. Progression to severe dengue is difficult to diagnose at the onset of fever, which complicates patient triage, posing a socio-economic burden on health systems.<h4>Methods</h4>To identify parameters associated with protection and susceptibility to DHF, we pursued a systems immunology approach integrating plasma chemokine profiling, high-dimensional mass cytometry and peripheral blood mononuclear cell (PBMC) transcriptomic analysis at the onset of fever in a prospective study conducted in Indonesia.<h4>Result","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-04T23:00:40.825Z","creation":"2025-04-04T23:00:40.825Z"},"accession":"S-EPMC10103532","cross_references":{"pubmed":["37055751"],"doi":["10.1186/s12929-023-00916-4"]}}