{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Hahn J"],"funding":["NEI NIH HHS","NIMH NIH HHS","Wellcome Trust","NIGMS NIH HHS"],"pubmed_abstract":["The basic plan of the retina is conserved across vertebrates, yet species differ profoundly in their visual needs (Baden et al., 2020). One might expect that retinal cell types evolved to accommodate these varied needs, but this has not been systematically studied. Here, we generated and integrated single-cell transcriptomic atlases of the retina from 17 species: humans, two non-human primates, four rodents, three ungulates, opossum, ferret, tree shrew, a teleost fish, a bird, a reptile and a lamprey. Molecular conservation of the six retinal cell classes (photoreceptors, horizontal cells, bipolar cells, amacrine cells, retinal ganglion cells [RGCs] and Muller glia) is striking, with transcriptomic differences across species correlated with evolutionary distance. Major subclasses are also "],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.04.07.536039"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10104162"],"repository":["biostudies-literature"],"pubmed_title":["Evolution of neuronal cell classes and types in the vertebrate retina."],"pmcid":["PMC10104162"],"funding_grant_id":["K99 EY033457","210684/Z/18/Z","T32 GM007103","U01 MH105960","R21 EY028633","R00 EY028625"],"pubmed_authors":["Kunze VP","Richardson R","Trachtenberg JT","Lucas RJ","Peng YR","Meister M","Baier H","Monavarfeshani A","Hahn J","Sanes JR","Yan W","Li W","Kolsch Y","Kao A","Shekhar K","Rasys AM","Kumar A","Qiao M"],"additional_accession":[]},"is_claimable":false,"name":"Evolution of neuronal cell classes and types in the vertebrate retina.","description":"The basic plan of the retina is conserved across vertebrates, yet species differ profoundly in their visual needs (Baden et al., 2020). One might expect that retinal cell types evolved to accommodate these varied needs, but this has not been systematically studied. Here, we generated and integrated single-cell transcriptomic atlases of the retina from 17 species: humans, two non-human primates, four rodents, three ungulates, opossum, ferret, tree shrew, a teleost fish, a bird, a reptile and a lamprey. Molecular conservation of the six retinal cell classes (photoreceptors, horizontal cells, bipolar cells, amacrine cells, retinal ganglion cells [RGCs] and Muller glia) is striking, with transcriptomic differences across species correlated with evolutionary distance. Major subclasses are also ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-04-20T03:20:23.751Z","creation":"2025-04-05T10:55:10.025Z"},"accession":"S-EPMC10104162","cross_references":{"pubmed":["37066415"],"doi":["10.1101/2023.04.07.536039"]}}