biostudies-literatureO'Callaghan VSCentre of Research ExcellenceIntramural NIH HHSAustralian Government and the Imaging Genomics LaboratoryQueensland Brain InstituteNational Health and Medical Research CouncilYoung and Well Cooperative Research CentreIntramural Research Program of the National Institute of Mental HealthAustralian Government’s Cooperative Research Centres Programzpab018https://www.ebi.ac.uk/biostudies/studies/S-EPMC10104400biostudies-literatureUnknown2(1)<h4>Study objectives</h4>To investigate the influence of genetic and environmental factors on sleep-wake behaviors across adolescence.<h4>Methods</h4>Four hundred and ninety-five participants (aged 9-17; 55% females), including 93 monozygotic and 117 dizygotic twin pairs, and 75 unmatched twins, wore an accelerometry device and completed a sleep diary for 2 weeks.<h4>Results</h4>Individual differences in sleep onset, wake time, and sleep midpoint were influenced by both additive genetic (44%-50% of total variance) and shared environmental (31%-42%) factors, with a predominant genetic influence for sleep duration (62%) and restorative sleep (43%). When stratified into younger (aged 9-14) and older (aged 16-17) subsamples, genetic sources were more prominent in older adolescents. The moderate correlation between sleep duration and midpoint (<i>r</i>P = -.43, <i>r</i>G = .54) was attributable to a common genetic source. Sleep-wake behaviors on school and nonschool nights were correlated (<i>r</i>P = .44-.72) and influenced by the same genetic and unique environmental factors. Genetic sources specific to night-type were also identified, for all behaviors except restorative sleep.<h4>Conclusions</h4>There were strong genetic influences on sleep-wake phenotypes, particularly on sleep timing, in adolescence. Moreover, there may be common genetic influences underlying both sleep and circadian rhythms. The differences in sleep-wake behaviors on school and nonschool nights could be attributable to genetic factors involved in reactivity to environmental context.Sleep advances : a journal of the Sleep Research SocietyGenetic and environmental influences on sleep-wake behaviors in adolescence.PMC101044001078756103111910781022014-2016Z01 MH0028045524851049894Z-01-MH002804Martin NGHickie IBGuo WCarpenter JSMerikangas KRStrike LTShou HBurns JMMcMahon KLByrne EMCrouse JJHansell NKO'Callaghan VSMcAloney KWright MJfalseGenetic and environmental influences on sleep-wake behaviors in adolescence.<h4>Study objectives</h4>To investigate the influence of genetic and environmental factors on sleep-wake behaviors across adolescence.<h4>Methods</h4>Four hundred and ninety-five participants (aged 9-17; 55% females), including 93 monozygotic and 117 dizygotic twin pairs, and 75 unmatched twins, wore an accelerometry device and completed a sleep diary for 2 weeks.<h4>Results</h4>Individual differences in sleep onset, wake time, and sleep midpoint were influenced by both additive genetic (44%-50% of total variance) and shared environmental (31%-42%) factors, with a predominant genetic influence for sleep duration (62%) and restorative sleep (43%). When stratified into younger (aged 9-14) and older (aged 16-17) subsamples, genetic sources were more prominent in older adolescents. The moderate correlation between sleep duration and midpoint (<i>r</i>P = -.43, <i>r</i>G = .54) was attributable to a common genetic source. Sleep-wake behaviors on school and nonschool nights were correlated (<i>r</i>P = .44-.72) and influenced by the same genetic and unique environmental factors. Genetic sources specific to night-type were also identified, for all behaviors except restorative sleep.<h4>Conclusions</h4>There were strong genetic influences on sleep-wake phenotypes, particularly on sleep timing, in adolescence. Moreover, there may be common genetic influences underlying both sleep and circadian rhythms. The differences in sleep-wake behaviors on school and nonschool nights could be attributable to genetic factors involved in reactivity to environmental context.2021-01-01T00:00:00Z20212026-05-28T08:22:24.586Z2025-04-05T21:07:37.207ZS-EPMC101044003719357010.1093/sleepadvances/zpab018