{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ottonello A"],"funding":["NCI NIH HHS","Biotechnology and Biological Sciences Research Council"],"pagination":["e2208737120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10104512"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(15)"],"pubmed_abstract":["The alarming rise in superbugs that are resistant to drugs of last resort, including vancomycin-resistant enterococci and staphylococci, has become a significant global health hazard. Here, we report the click chemistry synthesis of an unprecedented class of shapeshifting vancomycin dimers (SVDs) that display potent activity against bacteria that are resistant to the parent drug, including the ESKAPE pathogens, vancomycin-resistant <i>Enterococcus</i> (VRE), methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), as well as vancomycin-resistant <i>S. aureus</i> (VRSA). The shapeshifting modality of the dimers is powered by a triazole-linked bullvalene core, exploiting the dynamic covalent rearrangements of the fluxional carbon cage and creating ligands with the capacity to inhibit bacte"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria."],"pmcid":["PMC10104512"],"funding_grant_id":["P30 CA045508","BB/X002950/1"],"pubmed_authors":["Soares da Costa TP","Homer JA","Wyllie JA","Robinson CV","Yahiaoui O","Johnson RM","Fallon T","Ottonello A","Moses JE","Murray E","Koelln RA","Sun S","Williams P","Bolla JR"],"additional_accession":[]},"is_claimable":false,"name":"Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria.","description":"The alarming rise in superbugs that are resistant to drugs of last resort, including vancomycin-resistant enterococci and staphylococci, has become a significant global health hazard. Here, we report the click chemistry synthesis of an unprecedented class of shapeshifting vancomycin dimers (SVDs) that display potent activity against bacteria that are resistant to the parent drug, including the ESKAPE pathogens, vancomycin-resistant <i>Enterococcus</i> (VRE), methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), as well as vancomycin-resistant <i>S. aureus</i> (VRSA). The shapeshifting modality of the dimers is powered by a triazole-linked bullvalene core, exploiting the dynamic covalent rearrangements of the fluxional carbon cage and creating ligands with the capacity to inhibit bacte","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-05T15:23:16.6Z","creation":"2025-04-05T15:23:16.6Z"},"accession":"S-EPMC10104512","cross_references":{"pubmed":["37011186"],"doi":["10.1073/pnas.2208737120"]}}