{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pozo M"],"funding":["Ministerio de Ciencia, Innovación y Universidades (MCIU)","Ministerio de Ciencia, Innovación y Universidades","EC | Horizon 2020 Framework Programme (H2020)","EC | Horizon 2020 Framework Programme","Biotechnology and Biological Sciences Research Council"],"pagination":["e2218142120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10104524"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(15)"],"pubmed_abstract":["The internal state of an animal, including homeostatic requirements, modulates its behavior. Negative energy balance stimulates hunger, thus promoting a range of actions aimed at obtaining food. While these survival actions are well established, the influence of the energy status on prosocial behavior remains unexplored. We developed a paradigm to assess helping behavior in which a free mouse was faced with a conspecific trapped in a restrainer. We measured the willingness of the free mouse to liberate the confined mouse under diverse metabolic conditions. Around 42% of ad libitum-fed mice exhibited a helping behavior, as evidenced by the reduction in the latencies to release the trapped cagemate. This behavior was independent of subsequent social contact reward and was associated with cha"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Negative energy balance hinders prosocial helping behavior."],"pmcid":["PMC10104524"],"funding_grant_id":["BFU2015-72486-EXP","725004","BB/V016318/1"],"pubmed_authors":["Obri A","Costa-Font J","Ramirez S","Toledo M","Boudjadja MB","Eyre E","Gomez-Valades AG","Ben-Ami Bartal I","Haddad-Tovolli R","D'Agostino G","Pozo M","Chivite I","Mila-Guasch M","Claret M"],"additional_accession":[]},"is_claimable":false,"name":"Negative energy balance hinders prosocial helping behavior.","description":"The internal state of an animal, including homeostatic requirements, modulates its behavior. Negative energy balance stimulates hunger, thus promoting a range of actions aimed at obtaining food. While these survival actions are well established, the influence of the energy status on prosocial behavior remains unexplored. We developed a paradigm to assess helping behavior in which a free mouse was faced with a conspecific trapped in a restrainer. We measured the willingness of the free mouse to liberate the confined mouse under diverse metabolic conditions. Around 42% of ad libitum-fed mice exhibited a helping behavior, as evidenced by the reduction in the latencies to release the trapped cagemate. This behavior was independent of subsequent social contact reward and was associated with cha","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-05-28T16:08:13.822Z","creation":"2025-04-06T10:18:42.633Z"},"accession":"S-EPMC10104524","cross_references":{"pubmed":["37023123"],"doi":["10.1073/pnas.2218142120"]}}