{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guo J"],"funding":["Scientific Research Foundation of Reproductive and Genetic Hospital of CITIC-Xiangya","Natural Science Foundation of Hunan Province","National Natural Science Foundation of China"],"pagination":["e2205500"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10104655"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(11)"],"pubmed_abstract":["Maternal messenger ribonucleic acids (mRNAs) are driven by a highly orchestrated scheme of recruitment to polysomes and translational activation. However, selecting and regulating individual mRNAs for the translation from a competitive pool of mRNAs are little-known processes. This research shows that the maternal eukaryotic translation initiation factor 4e1b (Eif4e1b) expresses during the oocyte-to-embryo transition (OET), and maternal deletion of Eif4e1b leads to multiple defects concerning oogenesis and embryonic developmental competence during OET. The linear amplification of complementary deoxyribonucleic acid (cDNA) ends, and sequencing (LACE-seq) is used to identify the distinct subset of mRNA and its CG-rich binding sites within the 5' untranslated region (UTR) targeted by eIF4E1B."],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition."],"pmcid":["PMC10104655"],"funding_grant_id":["YNXM-202208","32130064","YNXM-202103","82201842","81901473","2020JJ5991","YNXM-201810"],"pubmed_authors":["Zhang J","Lv X","Zhang S","Zheng W","Xue Y","Meng F","Gong F","Su R","Guo J","Lu G","Lin G","Dai J","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition.","description":"Maternal messenger ribonucleic acids (mRNAs) are driven by a highly orchestrated scheme of recruitment to polysomes and translational activation. However, selecting and regulating individual mRNAs for the translation from a competitive pool of mRNAs are little-known processes. This research shows that the maternal eukaryotic translation initiation factor 4e1b (Eif4e1b) expresses during the oocyte-to-embryo transition (OET), and maternal deletion of Eif4e1b leads to multiple defects concerning oogenesis and embryonic developmental competence during OET. The linear amplification of complementary deoxyribonucleic acid (cDNA) ends, and sequencing (LACE-seq) is used to identify the distinct subset of mRNA and its CG-rich binding sites within the 5' untranslated region (UTR) targeted by eIF4E1B.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-06-05T06:49:08.208Z","creation":"2025-04-04T12:44:59.94Z"},"accession":"S-EPMC10104655","cross_references":{"pubmed":["36755190"],"doi":["10.1002/advs.202205500"]}}