{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu Y"],"funding":["Fundamental Research Funds for the Central Universities","Guangzhou Key R&D Program Project","National Key R&D Program of China","Frontier Research Program of Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)","Guangdong Scientific and Technological Project","Guangdong Province Key Field R&D Program","National Natural Science Foundation of China"],"pagination":["e2205878"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10104657"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(11)"],"pubmed_abstract":["Blindness caused by corneal damage affects millions of people worldwide, and this number continues to rise. However, rapid epithelization and a stable epithelium process are the two biggest challenges for traditional corneal materials. These processes are related to corneal curvature, which is an important factor in determination of the corneal healing process and epithelial behavior during corneal damage. In this study, smooth 3D-printed convex corneal implants based on gelatin methacrylate and collagen are generated. As epithelium distribution and adhesion vary in different regions of the natural cornea, this work separates the surfaces into four regions and studies how cells sense topological cues on curvature. It is found that rabbit corneal epithelial cells (RCECs) seeded on steeper s"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Biomimetic Convex Implant for Corneal Regeneration Through 3D Printing."],"pmcid":["PMC10104657"],"funding_grant_id":["2018GZR110105008","52173123","2019B010941002","2020B1111150002","202206010160","2017YFC1105000","11932017","2021A1515010878"],"pubmed_authors":["Li H","Peng Y","Liu J","Ji B","Wang Q","Huang Y","Ren L","Zhao Q","Sun X","Song W","Yuan J","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Biomimetic Convex Implant for Corneal Regeneration Through 3D Printing.","description":"Blindness caused by corneal damage affects millions of people worldwide, and this number continues to rise. However, rapid epithelization and a stable epithelium process are the two biggest challenges for traditional corneal materials. These processes are related to corneal curvature, which is an important factor in determination of the corneal healing process and epithelial behavior during corneal damage. In this study, smooth 3D-printed convex corneal implants based on gelatin methacrylate and collagen are generated. As epithelium distribution and adhesion vary in different regions of the natural cornea, this work separates the surfaces into four regions and studies how cells sense topological cues on curvature. It is found that rabbit corneal epithelial cells (RCECs) seeded on steeper s","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-04T23:00:48.556Z","creation":"2025-04-04T23:00:48.556Z"},"accession":"S-EPMC10104657","cross_references":{"pubmed":["36775872"],"doi":["10.1002/advs.202205878"]}}