{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McBride DA"],"funding":["NIDCR NIH HHS","NCATS NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NCI NIH HHS","National Institutes of Health","NIAMS NIH HHS","NIH HHS","National Science Foundation"],"pagination":["e2202720"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10104670"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(11)"],"pubmed_abstract":["Disease modifying antirheumatic drugs (DMARDs) have improved the prognosis of autoimmune inflammatory arthritides but a large fraction of patients display partial or nonresponsiveness to front-line DMARDs. Here, an immunoregulatory approach based on sustained joint-localized release of all-trans retinoic acid (ATRA), which modulates local immune activation and enhances disease-protective T cells and leads to systemic disease control is reported. ATRA imprints a unique chromatin landscape in T cells, which is associated with an enhancement in the differentiation of naïve T cells into anti-inflammatory regulatory T cells (T<sub>reg</sub> ) and suppression of T<sub>reg</sub> destabilization. Sustained release poly-(lactic-co-glycolic) acid (PLGA)-based biodegradable microparticles encapsulati"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis."],"pmcid":["PMC10104670"],"funding_grant_id":["R01 AI148073","UL1TR001442","S10 OD025052","F31AR079921(D.A.M.)","F31 AR079921","UL1 TR001442","R03DE031009(N.J.S)","R01 AR065466","T32AR064194","R01AI148073(N.B.)","S10OD025052","T32CA153915","P30AR073761(N.B.)","R03 DE031009","P30 AR073761","P30CA23100","T32 AR064194","P30 CA023100","ECCS‐2025752","T32 CA153915","F31 HL164055","F31HL164055(M.D.K.)"],"pubmed_authors":["Svensson MND","Bottini N","Shah NJ","Dorn NC","McBride DA","Yao M","Prideaux EB","Kerr MD","Nguyen A","Wang W","Johnson WT","Zoccheddu M"],"additional_accession":[]},"is_claimable":false,"name":"Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis.","description":"Disease modifying antirheumatic drugs (DMARDs) have improved the prognosis of autoimmune inflammatory arthritides but a large fraction of patients display partial or nonresponsiveness to front-line DMARDs. Here, an immunoregulatory approach based on sustained joint-localized release of all-trans retinoic acid (ATRA), which modulates local immune activation and enhances disease-protective T cells and leads to systemic disease control is reported. ATRA imprints a unique chromatin landscape in T cells, which is associated with an enhancement in the differentiation of naïve T cells into anti-inflammatory regulatory T cells (T<sub>reg</sub> ) and suppression of T<sub>reg</sub> destabilization. Sustained release poly-(lactic-co-glycolic) acid (PLGA)-based biodegradable microparticles encapsulati","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-04T23:00:59.362Z","creation":"2025-04-04T23:00:59.362Z"},"accession":"S-EPMC10104670","cross_references":{"pubmed":["36890657"],"doi":["10.1002/advs.202202720"]}}