biostudies-literatureUnknown2023Peng B<h4>Background</h4>Necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) are the major contributors to mortality and morbidity in preterm infants. This updated meta-analysis was aimed to assess the effects of mother's milk on the incidence of NEC, LOS, and other clinical outcomes in preterm infants.<h4>Methods</h4>PubMed, Embase, and the Cochrane library were searched for papers published up to October 2022.<h4>Results</h4>A total of 13 RCTs with 1330 infants were included in the final analysis. Significant difference in NEC (stage 2 or 3) was found between the intervention group and the control group (RR = 0.508, 95% CI: 0.314-0.822, and <i>P</i>=0.008). The incidence of proven LOS (RR = 0.809, 95% CI: 0.610-1.071, and <i>P</i>=0.139) and death (RR = 0.800, 95% CI: 0.571-1.122, and Evidence-based complementary and alternative medicine : eCAM7378064https://www.ebi.ac.uk/biostudies/studies/S-EPMC10104743biostudies-literatureOral Application of Mother's Own Milk for Reducing Necrotizing Enterocolitis in Preterm Infants: An Updated Meta-Analysis of RCTs.PMC10104743Yu LQian JPeng BZhang YZheng BZhu CfalseOral Application of Mother's Own Milk for Reducing Necrotizing Enterocolitis in Preterm Infants: An Updated Meta-Analysis of RCTs.<h4>Background</h4>Necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) are the major contributors to mortality and morbidity in preterm infants. This updated meta-analysis was aimed to assess the effects of mother's milk on the incidence of NEC, LOS, and other clinical outcomes in preterm infants.<h4>Methods</h4>PubMed, Embase, and the Cochrane library were searched for papers published up to October 2022.<h4>Results</h4>A total of 13 RCTs with 1330 infants were included in the final analysis. Significant difference in NEC (stage 2 or 3) was found between the intervention group and the control group (RR = 0.508, 95% CI: 0.314-0.822, and <i>P</i>=0.008). The incidence of proven LOS (RR = 0.809, 95% CI: 0.610-1.071, and <i>P</i>=0.139) and death (RR = 0.800, 95% CI: 0.571-1.122, and 2023-01-01T00:00:00Z20232025-04-04T12:43:47.471Z2025-04-04T12:43:47.471ZS-EPMC101047433706494510.1155/2023/7378064