biostudies-literatureUnknown16(2)Buch JJohnson and Johnson Vision Care<h4>Purpose</h4>Evaluate the performance of a photochromic contact lens in various lighting conditions throughout the day, including those indoor and outdoor environments where the photochromic contact lens is in a less active or inactive state.<h4>Methods</h4>Data from two clinical trials of a photochromic contact lens were analyzed to evaluate its performance in various light environments. Both studies involved a photochromic test lens (ACUVUE® OASYS with Transitions™ Light Intelligent Technology™) and a similar non-photochromic control lens (ACUVUE® OASYS 2-week with HYDRACLEAR® PLUS). The studies were both multi-visit, multi-site, 2-treatment by 3-period randomized crossover (i.e., Test/Control/Control or Control/Test/Test) dispensing studies, with follow-up visits after each 2-week diJournal of optometry135-142https://www.ebi.ac.uk/biostudies/studies/S-EPMC10104794biostudies-literatureUnexpected vision performance with photochromic contact lenses in normal and low light conditions: An analysis of two randomized trials.PMC10104794Sonoda LCannon JBuch JfalseUnexpected vision performance with photochromic contact lenses in normal and low light conditions: An analysis of two randomized trials.<h4>Purpose</h4>Evaluate the performance of a photochromic contact lens in various lighting conditions throughout the day, including those indoor and outdoor environments where the photochromic contact lens is in a less active or inactive state.<h4>Methods</h4>Data from two clinical trials of a photochromic contact lens were analyzed to evaluate its performance in various light environments. Both studies involved a photochromic test lens (ACUVUE® OASYS with Transitions™ Light Intelligent Technology™) and a similar non-photochromic control lens (ACUVUE® OASYS 2-week with HYDRACLEAR® PLUS). The studies were both multi-visit, multi-site, 2-treatment by 3-period randomized crossover (i.e., Test/Control/Control or Control/Test/Test) dispensing studies, with follow-up visits after each 2-week di2023-01-01T00:00:00Z2023 Apr-Jun2026-05-28T17:53:01.997Z2025-04-04T14:30:38.134ZS-EPMC101047943595343010.1016/j.optom.2022.06.004