{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shang M"],"funding":["National Natural Science Foundation of China"],"pagination":["414"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10104844"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(1)"],"pubmed_abstract":["Light exposure can profoundly affect neurological functions and behaviors. Here, we show that short-term exposure to moderate (400 lux) white light during Y-maze test promoted spatial memory retrieval and induced only mild anxiety in mice. This beneficial effect involves the activation of a circuit including neurons in the central amygdala (CeA), locus coeruleus (LC), and dentate gyrus (DG). Specifically, moderate light activated corticotropin-releasing hormone (CRH) positive (+) CeA neurons and induced the release of corticotropin-releasing factor (CRF) from their axon terminals ending in the LC. CRF then activated tyrosine hydroxylase-expressing LC neurons, which send projections to DG and release norepinephrine (NE). NE activated β-adrenergic receptors on CaMKIIα-expressing DG neurons, "],"journal":["Communications biology"],"pubmed_title":["Moderate white light exposure enhanced spatial memory retrieval by activating a central amygdala-involved circuit in mice."],"pmcid":["PMC10104844"],"funding_grant_id":["51437008","31671089"],"pubmed_authors":["Shen M","Han Q","Li J","Hu Y","Zhang J","Wang B","Xu R","Sun Z","Liu Y","Xing J","Guan Y","OuYang D","Shang M","Hu J","Guo G","Du J"],"additional_accession":[]},"is_claimable":false,"name":"Moderate white light exposure enhanced spatial memory retrieval by activating a central amygdala-involved circuit in mice.","description":"Light exposure can profoundly affect neurological functions and behaviors. Here, we show that short-term exposure to moderate (400 lux) white light during Y-maze test promoted spatial memory retrieval and induced only mild anxiety in mice. This beneficial effect involves the activation of a circuit including neurons in the central amygdala (CeA), locus coeruleus (LC), and dentate gyrus (DG). Specifically, moderate light activated corticotropin-releasing hormone (CRH) positive (+) CeA neurons and induced the release of corticotropin-releasing factor (CRF) from their axon terminals ending in the LC. CRF then activated tyrosine hydroxylase-expressing LC neurons, which send projections to DG and release norepinephrine (NE). NE activated β-adrenergic receptors on CaMKIIα-expressing DG neurons, ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-04T23:00:47.221Z","creation":"2025-04-04T23:00:47.221Z"},"accession":"S-EPMC10104844","cross_references":{"pubmed":["37059729"],"doi":["10.1038/s42003-023-04765-7"]}}