{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Albariqi MM"],"funding":["King Abdulaziz City for Science and Technology (KACST), Saudi Arabia"],"pagination":["e156993"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10104883"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["133(8)"],"pubmed_abstract":["Peripheral neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). We investigated whether human islet amyloid polypeptide (hIAPP), which forms pathogenic aggregates that damage pancreatic islet β cells in T2DM, is involved in T2DM-associated peripheral neuropathy. In vitro, hIAPP incubation with sensory neurons reduced neurite outgrowth and increased levels of mitochondrial reactive oxygen species. hIAPP-transgenic mice, which have elevated plasma hIAPP levels without hyperglycemia, developed peripheral neuropathy as evidenced by pain-associated behavior and reduced intraepidermal nerve fiber (IENF) density. Similarly, hIAPP Ob/Ob mice, which have hyperglycemia in combination with elevated plasma hIAPP levels, had signs of neuropathy, although more aggravated. In wild-ty"],"journal":["The Journal of clinical investigation"],"pubmed_title":["Human IAPP is a contributor to painful diabetic peripheral neuropathy."],"pmcid":["PMC10104883"],"funding_grant_id":["69082/1438/M"],"pubmed_authors":["Coert JH","Prado J","Versteeg S","Elenbaas BO","Eijkelkamp N","Albariqi MM","Hack CE","Hoppener JW","Brakkee EM"],"additional_accession":[]},"is_claimable":false,"name":"Human IAPP is a contributor to painful diabetic peripheral neuropathy.","description":"Peripheral neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). We investigated whether human islet amyloid polypeptide (hIAPP), which forms pathogenic aggregates that damage pancreatic islet β cells in T2DM, is involved in T2DM-associated peripheral neuropathy. In vitro, hIAPP incubation with sensory neurons reduced neurite outgrowth and increased levels of mitochondrial reactive oxygen species. hIAPP-transgenic mice, which have elevated plasma hIAPP levels without hyperglycemia, developed peripheral neuropathy as evidenced by pain-associated behavior and reduced intraepidermal nerve fiber (IENF) density. Similarly, hIAPP Ob/Ob mice, which have hyperglycemia in combination with elevated plasma hIAPP levels, had signs of neuropathy, although more aggravated. In wild-ty","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-04T22:59:56.401Z","creation":"2025-04-04T22:59:56.401Z"},"accession":"S-EPMC10104883","cross_references":{"pubmed":["36917177"],"doi":["10.1172/JCI156993"]}}