{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Farr JN"],"funding":["NIA NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","National Cancer Institute","NCI NIH HHS","National Institute on Aging"],"pagination":["e162519"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10104901"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["133(8)"],"pubmed_abstract":["Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction remain unclear. Thus, we developed a mouse model (p16-LOX-ATTAC) that allowed for inducible SnC elimination (senolysis) in a cell-specific manner and compared the effects of local versus systemic senolysis during aging using bone as a prototype tissue. Specific removal of Sn osteocytes prevented age-related bone loss at the spine, but not the femur, by improving bone formation without affecting osteoclasts or marrow adipocytes. By contrast, systemic senolysis prevented bone loss at the spine and femur and not only improved bone formation, but also reduced osteoclast and marrow adipocyte numbers. Transplantatio"],"journal":["The Journal of clinical investigation"],"pubmed_title":["Local senolysis in aged mice only partially replicates the benefits of systemic senolysis."],"pmcid":["PMC10104901"],"funding_grant_id":["R01 AG068048","AG062413,AG076515,AG068048,AG013925,AG063543,AG056278,AG063707","DK128552","UG3CA26810","UG3 CA268103"],"pubmed_authors":["Rowsey JL","Jurk D","Zhu Y","Saul D","Niedernhofer LJ","Passos JF","Vos SJ","Lagnado AB","Weivoda M","Tchkonia T","Doolittle ML","Kaur J","Robbins PD","LeBrasseur NK","Froemming MN","Khosla S","Kirkland JL","Farr JN","Pignolo RJ","Ikeno Y","Monroe DG"],"additional_accession":[]},"is_claimable":false,"name":"Local senolysis in aged mice only partially replicates the benefits of systemic senolysis.","description":"Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction remain unclear. Thus, we developed a mouse model (p16-LOX-ATTAC) that allowed for inducible SnC elimination (senolysis) in a cell-specific manner and compared the effects of local versus systemic senolysis during aging using bone as a prototype tissue. Specific removal of Sn osteocytes prevented age-related bone loss at the spine, but not the femur, by improving bone formation without affecting osteoclasts or marrow adipocytes. By contrast, systemic senolysis prevented bone loss at the spine and femur and not only improved bone formation, but also reduced osteoclast and marrow adipocyte numbers. Transplantatio","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-18T15:01:07.375Z","creation":"2025-04-07T01:27:32.336Z"},"accession":"S-EPMC10104901","cross_references":{"pubmed":["36809340"],"doi":["10.1172/JCI162519"]}}