biostudies-literatureGarcia-Hermoso AInstituto de Salud Carlos III147-157https://www.ebi.ac.uk/biostudies/studies/S-EPMC10105032biostudies-literatureUnknown12(2)<h4>Background</h4>This study investigates the effects of exercise training on exerkines in patients with type 2 diabetes mellitus to determine the optimal exercise prescription.<h4>Methods</h4>A systematic search for relevant studies was performed in 3 databases. Randomized controlled trials investigating the effects of exercise training on at least one of the following exerkines were included: adiponectin, apelin, brain-derived neurotrophic factor, fetuin-A, fibroblast growth factor-21, follistatin, ghrelin, interleukin (IL)-6, IL-8, IL-10, IL-15, IL-18, leptin, myostatin, omentin, resistin, retinol-binding protein 4, tumor necrosis factor-α, and visfatin.<h4>Results</h4>Forty randomized controlled trials were selected for data extraction (n = 2160). Exercise training induces changes in Journal of sport and health scienceExercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials.PMC10105032III – CP18/0150Diez JGarcia-Hermoso AIzquierdo MRamirez-Velez RGonzalez AfalseExercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials.<h4>Background</h4>This study investigates the effects of exercise training on exerkines in patients with type 2 diabetes mellitus to determine the optimal exercise prescription.<h4>Methods</h4>A systematic search for relevant studies was performed in 3 databases. Randomized controlled trials investigating the effects of exercise training on at least one of the following exerkines were included: adiponectin, apelin, brain-derived neurotrophic factor, fetuin-A, fibroblast growth factor-21, follistatin, ghrelin, interleukin (IL)-6, IL-8, IL-10, IL-15, IL-18, leptin, myostatin, omentin, resistin, retinol-binding protein 4, tumor necrosis factor-α, and visfatin.<h4>Results</h4>Forty randomized controlled trials were selected for data extraction (n = 2160). Exercise training induces changes in 2023-01-01T00:00:00Z2023 Mar2025-05-18T11:13:05.368Z2025-05-18T11:13:05.368ZS-EPMC101050323635154510.1016/j.jshs.2022.11.003