{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(4)"],"submitter":["Park S"],"pubmed_abstract":["Introduction
Selenium is a trace mineral that is commonly included in micronutrient supplements. The effect of selenium on kidney function remains unclear. A genetically predicted micronutrient and its association with estimated glomerular filtration rate (eGFR) can be used to assess the causal estimates by Mendelian randomization (MR).Methods
In this MR study, we instrumented 11 genetic variants associated with blood or total selenium levels from a previous genome-wide association study (GWAS). The association between genetically predicted selenium concentration and eGFR was first assessed by summary-level MR in the chronic kidney disease(CKDGen) GWAS meta-analysis summary statistics, including 567,460 European samples. Inverse-variance weighted and pleiotropy-robust MR an"],"journal":["Kidney international reports"],"pagination":["851-859"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10105058"],"repository":["biostudies-literature"],"pubmed_title":["Genetically Predicted Body Selenium Concentration and estimated GFR: A Mendelian Randomization Study."],"pmcid":["PMC10105058"],"pubmed_authors":["Lee S","Kim K","Lee H","Lim CS","Park S","Han SS","Kim DK","Kim YC","Kim SG","Lee JP","Joo KW","Kim Y","Cho S","Kim YS"],"additional_accession":[]},"is_claimable":false,"name":"Genetically Predicted Body Selenium Concentration and estimated GFR: A Mendelian Randomization Study.","description":"Introduction
Selenium is a trace mineral that is commonly included in micronutrient supplements. The effect of selenium on kidney function remains unclear. A genetically predicted micronutrient and its association with estimated glomerular filtration rate (eGFR) can be used to assess the causal estimates by Mendelian randomization (MR).Methods
In this MR study, we instrumented 11 genetic variants associated with blood or total selenium levels from a previous genome-wide association study (GWAS). The association between genetically predicted selenium concentration and eGFR was first assessed by summary-level MR in the chronic kidney disease(CKDGen) GWAS meta-analysis summary statistics, including 567,460 European samples. Inverse-variance weighted and pleiotropy-robust MR an","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-18T15:00:51.649Z","creation":"2025-04-07T01:27:17.721Z"},"accession":"S-EPMC10105058","cross_references":{"pubmed":["37069993"],"doi":["10.1016/j.ekir.2023.01.009"]}}