biostudies-literatureUnknown8(4)Park S<h4>Introduction</h4>Selenium is a trace mineral that is commonly included in micronutrient supplements. The effect of selenium on kidney function remains unclear. A genetically predicted micronutrient and its association with estimated glomerular filtration rate (eGFR) can be used to assess the causal estimates by Mendelian randomization (MR).<h4>Methods</h4>In this MR study, we instrumented 11 genetic variants associated with blood or total selenium levels from a previous genome-wide association study (GWAS). The association between genetically predicted selenium concentration and eGFR was first assessed by summary-level MR in the chronic kidney disease(CKDGen) GWAS meta-analysis summary statistics, including 567,460 European samples. Inverse-variance weighted and pleiotropy-robust MR anKidney international reports851-859https://www.ebi.ac.uk/biostudies/studies/S-EPMC10105058biostudies-literatureGenetically Predicted Body Selenium Concentration and estimated GFR: A Mendelian Randomization Study.PMC10105058Lee SKim KLee HLim CSPark SHan SSKim DKKim YCKim SGLee JPJoo KWKim YCho SKim YSfalseGenetically Predicted Body Selenium Concentration and estimated GFR: A Mendelian Randomization Study.<h4>Introduction</h4>Selenium is a trace mineral that is commonly included in micronutrient supplements. The effect of selenium on kidney function remains unclear. A genetically predicted micronutrient and its association with estimated glomerular filtration rate (eGFR) can be used to assess the causal estimates by Mendelian randomization (MR).<h4>Methods</h4>In this MR study, we instrumented 11 genetic variants associated with blood or total selenium levels from a previous genome-wide association study (GWAS). The association between genetically predicted selenium concentration and eGFR was first assessed by summary-level MR in the chronic kidney disease(CKDGen) GWAS meta-analysis summary statistics, including 567,460 European samples. Inverse-variance weighted and pleiotropy-robust MR an2023-01-01T00:00:00Z2023 Apr2025-04-18T15:00:51.649Z2025-04-07T01:27:17.721ZS-EPMC101050583706999310.1016/j.ekir.2023.01.009