{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(1)"],"submitter":["Hu Y"],"pubmed_abstract":["<h4>Background</h4>RNA-binding motif protein 14 (RBM14) is upregulated in a variety of tumors. However, the expression and biological role of RBM14 in lung cancer remain unclear.<h4>Methods</h4>Chromatin immunoprecipitation and PCR were carried out to measure the levels of sedimentary YY1, EP300, H3K9ac, and H3K27ac in the RBM14 promoter. Co-immunoprecipitation was used to verify the interaction between YY1 and EP300. Glycolysis was investigated according to glucose consumption, lactate production, and the extracellular acidification rate (ECAR).<h4>Results</h4>RBM14 level is increased in lung adenocarcinoma (LUAD) cells. The increased RBM14 expression was correlated with TP53 mutation and individual cancer stages. A high level of RBM14 predicted a poorer overall survival of LUAD patients."],"journal":["World journal of surgical oncology"],"pagination":["132"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10105460"],"repository":["biostudies-literature"],"pubmed_title":["RBM14 as a novel epigenetic-activated tumor oncogene is implicated in the reprogramming of glycolysis in lung cancer."],"pmcid":["PMC10105460"],"pubmed_authors":["Hu Y","Mu H","Deng Z"],"additional_accession":[]},"is_claimable":false,"name":"RBM14 as a novel epigenetic-activated tumor oncogene is implicated in the reprogramming of glycolysis in lung cancer.","description":"<h4>Background</h4>RNA-binding motif protein 14 (RBM14) is upregulated in a variety of tumors. However, the expression and biological role of RBM14 in lung cancer remain unclear.<h4>Methods</h4>Chromatin immunoprecipitation and PCR were carried out to measure the levels of sedimentary YY1, EP300, H3K9ac, and H3K27ac in the RBM14 promoter. Co-immunoprecipitation was used to verify the interaction between YY1 and EP300. Glycolysis was investigated according to glucose consumption, lactate production, and the extracellular acidification rate (ECAR).<h4>Results</h4>RBM14 level is increased in lung adenocarcinoma (LUAD) cells. The increased RBM14 expression was correlated with TP53 mutation and individual cancer stages. A high level of RBM14 predicted a poorer overall survival of LUAD patients.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-05-29T14:37:41.591Z","creation":"2024-10-19T01:47:24.839Z"},"accession":"S-EPMC10105460","cross_references":{"pubmed":["37060064"],"doi":["10.1186/s12957-023-02928-8"]}}