biostudies-literatureXu Lthe Wenzhou Municipal Technological Innovation Program of High-level Talentsthe Key Innovation and Guidance Program of the Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical Universitythe Key R&D Program of Zhejiangthe Zhejiang Provincial National Science Foundation of Chinathe Health Commission of Zhejiang Provincethe Zhejiang Health Innovation Talents Programthe National Key R&D Program of Chinathe National Natural Science Foundation of China366-370https://www.ebi.ac.uk/biostudies/studies/S-EPMC10106402biostudies-literatureUnknown24(4)Glaucoma is one of the most common optic neuropathies, featuring progressive retinal ganglion cell damage and visual field loss (Tham et al., 2014; Xu et al., 2020). Currently, the only effective treatment for this condition is the reduction of intraocular pressure (IOP) (Palmberg, 2001; Heijl et al., 2002). Canaloplasty is a proven bleb-independent surgery with good efficacy and safety profiles in primary open-angle glaucoma (POAG) (Gołaszewska et al., 2021). However, early transient postoperative IOP elevation has been reported in up to 30% of cases (Riva et al., 2019), similar to that commonly observed in other internal drainage glaucoma surgeries such as implantation using iStent (0%-21.0%), CyPass (10.8%), and Hydrus (4.8%-6.5%) (Lavia et al., 2017). This complication may be a predictJournal of Zhejiang University. Science. BIncidence and risk factors of early transient intraocular pressure elevation after canaloplasty for primary open-angle glaucoma.PMC101064022023KY9142020YFC2008200YNZD22019032022C031122016025LQ18H120010604090352/57782201177Xu LLi JLiang YZhang XCao YGu JYe WWang XZhao YRen RfalseIncidence and risk factors of early transient intraocular pressure elevation after canaloplasty for primary open-angle glaucoma.Glaucoma is one of the most common optic neuropathies, featuring progressive retinal ganglion cell damage and visual field loss (Tham et al., 2014; Xu et al., 2020). Currently, the only effective treatment for this condition is the reduction of intraocular pressure (IOP) (Palmberg, 2001; Heijl et al., 2002). Canaloplasty is a proven bleb-independent surgery with good efficacy and safety profiles in primary open-angle glaucoma (POAG) (Gołaszewska et al., 2021). However, early transient postoperative IOP elevation has been reported in up to 30% of cases (Riva et al., 2019), similar to that commonly observed in other internal drainage glaucoma surgeries such as implantation using iStent (0%-21.0%), CyPass (10.8%), and Hydrus (4.8%-6.5%) (Lavia et al., 2017). This complication may be a predict2023-01-01T00:00:00Z2023 Apr2025-04-18T15:01:50.983Z2025-04-07T01:29:27.489ZS-EPMC101064023705621310.1631/jzus.b220048510.1631/jzus.B2200485