{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21"],"submitter":["Hayashi K"],"pubmed_abstract":["Synthetic bone grafts are in high demand owing to increased age-related bone disorders in the global aging population. Here, we report fabrication of gear-shaped granules (G-GRNs) for rapid bone healing. G-GRNs possessed six protrusions and a hexagonal macropore in the granular center. These were composed of carbonate apatite, i.e., bone mineral, microspheres with ∼1-μm micropores in the spaces between the microspheres. G-GRNs formed new bone and blood vessels (both on the granular surface and within the macropores) 4 weeks after implantation in the rabbit femur defects. The formed bone structure was similar to that of cancellous bone. The bone percentage in the defect recovered to that in a normal rabbit femur at week-4 post-implantation, and the bone percentage remained constant for the "],"journal":["Computational and structural biotechnology journal"],"pagination":["2514-2523"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10106487"],"repository":["biostudies-literature"],"pubmed_title":["Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration."],"pmcid":["PMC10106487"],"pubmed_authors":["Hayashi K","Yanagisawa T","Kishida R","Tsuchiya A","Ishikawa K"],"additional_accession":[]},"is_claimable":false,"name":"Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration.","description":"Synthetic bone grafts are in high demand owing to increased age-related bone disorders in the global aging population. Here, we report fabrication of gear-shaped granules (G-GRNs) for rapid bone healing. G-GRNs possessed six protrusions and a hexagonal macropore in the granular center. These were composed of carbonate apatite, i.e., bone mineral, microspheres with ∼1-μm micropores in the spaces between the microspheres. G-GRNs formed new bone and blood vessels (both on the granular surface and within the macropores) 4 weeks after implantation in the rabbit femur defects. The formed bone structure was similar to that of cancellous bone. The bone percentage in the defect recovered to that in a normal rabbit femur at week-4 post-implantation, and the bone percentage remained constant for the ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-18T14:52:38.492Z","creation":"2025-04-07T01:12:03.052Z"},"accession":"S-EPMC10106487","cross_references":{"pubmed":["37077175"],"doi":["10.1016/j.csbj.2023.03.053"]}}