{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(1)"],"submitter":["Macdonald S"],"pubmed_abstract":["<h4>Purpose</h4>To investigate the effect of IV fluid resuscitation on endothelial glycocalyx (EG) shedding and activation of the vascular endothelium and inflammation.<h4>Materials and methods</h4>A planned biomarker sub-study of the REFRESH trial in which emergency department (ED) patients) with suspected sepsis and hypotension were randomised to a restricted fluid/early vasopressor regimen or IV fluid resuscitation with later vasopressors if required (usual care). Blood samples were collected at randomisation (T0) and at 3 h (T3), 6 h (T6)- and 24 h (T24) for measurement of a range of biomarkers if EG shedding, endothelial cell activation and inflammation.<h4>Results</h4>Blood samples were obtained in 95 of 99 enrolled patients (46 usual care, 49 restricted fluid). Differences in the ch"],"journal":["Intensive care medicine experimental"],"pagination":["21"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10106534"],"repository":["biostudies-literature"],"pubmed_title":["Effect of intravenous fluid volume on biomarkers of endothelial glycocalyx shedding and inflammation during initial resuscitation of sepsis."],"pmcid":["PMC10106534"],"pubmed_authors":["Leonard A","Vlad I","Macdonald S","Keijzers G","Mukherjee A","Harley A","Hazelwood S","REFRESH Trial Investigators","Fraser J","Shapiro NI","Winearls J","Taylor D","Burrows S","Ascencio-Lane JC","McCutcheon D","Hibbs M","O'Donoghue H","Fatovich D","Smart L","Wibrow B","Anstey M","Litton E","Burcham J","Bellomo R","Arendts G","Cooper D","Kinnear F","Bosio E","Brown S"],"additional_accession":[]},"is_claimable":false,"name":"Effect of intravenous fluid volume on biomarkers of endothelial glycocalyx shedding and inflammation during initial resuscitation of sepsis.","description":"<h4>Purpose</h4>To investigate the effect of IV fluid resuscitation on endothelial glycocalyx (EG) shedding and activation of the vascular endothelium and inflammation.<h4>Materials and methods</h4>A planned biomarker sub-study of the REFRESH trial in which emergency department (ED) patients) with suspected sepsis and hypotension were randomised to a restricted fluid/early vasopressor regimen or IV fluid resuscitation with later vasopressors if required (usual care). Blood samples were collected at randomisation (T0) and at 3 h (T3), 6 h (T6)- and 24 h (T24) for measurement of a range of biomarkers if EG shedding, endothelial cell activation and inflammation.<h4>Results</h4>Blood samples were obtained in 95 of 99 enrolled patients (46 usual care, 49 restricted fluid). Differences in the ch","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-22T10:03:28.996Z","creation":"2025-04-05T23:22:46.319Z"},"accession":"S-EPMC10106534","cross_references":{"pubmed":["37062769"],"doi":["10.1186/s40635-023-00508-4"]}}