{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Park J"],"funding":["NIAID NIH HHS","NHLBI NIH HHS","National Heart, Lung, and Blood Institute","NIMHD NIH HHS","National Institutes of Health","National Institute on Minority Health and Health Disparities","NIGMS NIH HHS"],"pagination":["1151780"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10106598"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14"],"pubmed_abstract":["Background
Monocytes and macrophages play a pivotal role in inflammation during acute SARS-CoV-2 infection. However, their contribution to the development of post-acute sequelae of SARS-CoV-2 infection (PASC) are not fully elucidated.Methods
A cross-sectional study was conducted comparing plasma cytokine and monocyte levels among three groups: participants with pulmonary PASC (PPASC) with a reduced predicted diffusing capacity for carbon monoxide [DLCOc, <80%; (PG)]; fully recovered from SARS-CoV-2 with no residual symptoms (recovered group, RG); and negative for SARS-CoV-2 (negative group, NG). The expressions of cytokines were measured in plasma of study cohort by Luminex assay. The percentages and numbers of monocyte subsets (classical, intermediate, and non-classical mo"],"journal":["Frontiers in immunology"],"pubmed_title":["Elevated circulating monocytes and monocyte activation in COVID-19 convalescent individuals."],"pmcid":["PMC10106598"],"funding_grant_id":["P30 GM114737","K12 HL143960","P30 AI027757","U54 MD007601","T37 MD008636","T37MD008638, U54MD007601, P30GM114737","P30AI027757","K12HL143960","U54 GM138062"],"pubmed_authors":["Devendra G","Ching LL","Dean LS","Park J","Shah P","Igno F","Gangcuangco LM","Awamura T","Nerurkar VR","Jiyarom B","Chow DC","Shikuma CM"],"additional_accession":[]},"is_claimable":false,"name":"Elevated circulating monocytes and monocyte activation in COVID-19 convalescent individuals.","description":"Background
Monocytes and macrophages play a pivotal role in inflammation during acute SARS-CoV-2 infection. However, their contribution to the development of post-acute sequelae of SARS-CoV-2 infection (PASC) are not fully elucidated.Methods
A cross-sectional study was conducted comparing plasma cytokine and monocyte levels among three groups: participants with pulmonary PASC (PPASC) with a reduced predicted diffusing capacity for carbon monoxide [DLCOc, <80%; (PG)]; fully recovered from SARS-CoV-2 with no residual symptoms (recovered group, RG); and negative for SARS-CoV-2 (negative group, NG). The expressions of cytokines were measured in plasma of study cohort by Luminex assay. The percentages and numbers of monocyte subsets (classical, intermediate, and non-classical mo","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-06-21T03:19:45.668Z","creation":"2025-04-07T01:11:46.091Z"},"accession":"S-EPMC10106598","cross_references":{"pubmed":["37077911"],"doi":["10.3389/fimmu.2023.1151780"]}}