biostudies-literaturePark JNIAID NIH HHSNHLBI NIH HHSNational Heart, Lung, and Blood InstituteNIMHD NIH HHSNational Institutes of HealthNational Institute on Minority Health and Health DisparitiesNIGMS NIH HHS1151780https://www.ebi.ac.uk/biostudies/studies/S-EPMC10106598biostudies-literatureUnknown14<h4>Background</h4>Monocytes and macrophages play a pivotal role in inflammation during acute SARS-CoV-2 infection. However, their contribution to the development of post-acute sequelae of SARS-CoV-2 infection (PASC) are not fully elucidated.<h4>Methods</h4>A cross-sectional study was conducted comparing plasma cytokine and monocyte levels among three groups: participants with pulmonary PASC (PPASC) with a reduced predicted diffusing capacity for carbon monoxide [DLCOc, <80%; (PG)]; fully recovered from SARS-CoV-2 with no residual symptoms (recovered group, RG); and negative for SARS-CoV-2 (negative group, NG). The expressions of cytokines were measured in plasma of study cohort by Luminex assay. The percentages and numbers of monocyte subsets (classical, intermediate, and non-classical moFrontiers in immunologyElevated circulating monocytes and monocyte activation in COVID-19 convalescent individuals.PMC10106598P30 GM114737K12 HL143960P30 AI027757U54 MD007601T37 MD008636T37MD008638, U54MD007601, P30GM114737P30AI027757K12HL143960U54 GM138062Devendra GChing LLDean LSPark JShah PIgno FGangcuangco LMAwamura TNerurkar VRJiyarom BChow DCShikuma CMfalseElevated circulating monocytes and monocyte activation in COVID-19 convalescent individuals.<h4>Background</h4>Monocytes and macrophages play a pivotal role in inflammation during acute SARS-CoV-2 infection. However, their contribution to the development of post-acute sequelae of SARS-CoV-2 infection (PASC) are not fully elucidated.<h4>Methods</h4>A cross-sectional study was conducted comparing plasma cytokine and monocyte levels among three groups: participants with pulmonary PASC (PPASC) with a reduced predicted diffusing capacity for carbon monoxide [DLCOc, <80%; (PG)]; fully recovered from SARS-CoV-2 with no residual symptoms (recovered group, RG); and negative for SARS-CoV-2 (negative group, NG). The expressions of cytokines were measured in plasma of study cohort by Luminex assay. The percentages and numbers of monocyte subsets (classical, intermediate, and non-classical mo2023-01-01T00:00:00Z20232026-06-21T03:19:45.668Z2025-04-07T01:11:46.091ZS-EPMC101065983707791110.3389/fimmu.2023.1151780