biostudies-literatureDrury NLNIEHS NIH HHS11https://www.ebi.ac.uk/biostudies/studies/S-EPMC10106898biostudies-literatureUnknown20(1)<h4>Background</h4>Interactions between air pollution and infectious agents are increasingly recognized and critical to identify, especially to protect vulnerable populations. Pregnancy represents a vulnerable period for influenza infection and air pollution exposure, yet interactions during pregnancy remain unclear. Maternal exposure to ultrafine particles (UFPs, [Formula: see text] 100 nm diameter), a class of particulate matter ubiquitous in urban environments, elicits unique pulmonary immune responses. We hypothesized that UFP exposure during pregnancy would lead to aberrant immune responses to influenza enhancing infection severity.<h4>Results</h4>Building from our well-characterized C57Bl/6N mouse model employing daily gestational UFP exposure from gestational day (GD) 0.5-13.5, we cParticle and fibre toxicologyMaternal exposure to ultrafine particles enhances influenza infection during pregnancy.PMC10106898T32 ES026568Tighe RMWright GAHoffmann ARJohnson NMRegan ATalcott SUShore RADrury NLMustapha TZhao JZhang RfalseMaternal exposure to ultrafine particles enhances influenza infection during pregnancy.<h4>Background</h4>Interactions between air pollution and infectious agents are increasingly recognized and critical to identify, especially to protect vulnerable populations. Pregnancy represents a vulnerable period for influenza infection and air pollution exposure, yet interactions during pregnancy remain unclear. Maternal exposure to ultrafine particles (UFPs, [Formula: see text] 100 nm diameter), a class of particulate matter ubiquitous in urban environments, elicits unique pulmonary immune responses. We hypothesized that UFP exposure during pregnancy would lead to aberrant immune responses to influenza enhancing infection severity.<h4>Results</h4>Building from our well-characterized C57Bl/6N mouse model employing daily gestational UFP exposure from gestational day (GD) 0.5-13.5, we c2023-01-01T00:00:00Z2023 Apr2025-05-29T19:44:52.957Z2025-05-29T19:44:52.957ZS-EPMC101068983706968010.1186/s12989-023-00521-1