{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li J"],"funding":["Natural Science Foundation of Shandong Province","National Natural Science Foundation of China"],"pagination":["e112401"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10106984"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(8)"],"pubmed_abstract":["The maintenance of sodium/potassium (Na<sup>+</sup> /K<sup>+</sup> ) homeostasis in plant cells is essential for salt tolerance. Plants export excess Na<sup>+</sup> out of cells mainly through the Salt Overly Sensitive (SOS) pathway, activated by a calcium signal; however, it is unknown whether other signals regulate the SOS pathway and how K<sup>+</sup> uptake is regulated under salt stress. Phosphatidic acid (PA) is emerging as a lipid signaling molecule that modulates cellular processes in development and the response to stimuli. Here, we show that PA binds to the residue Lys57 in SOS2, a core member of the SOS pathway, under salt stress, promoting the activity and plasma membrane localization of SOS2, which activates the Na<sup>+</sup> /H<sup>+</sup> antiporter SOS1 to promote the Na<s"],"journal":["The EMBO journal"],"pubmed_title":["Phosphatidic acid-regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress."],"pmcid":["PMC10106984"],"funding_grant_id":["32171956","32100234","ZR2020MC021","32270268","32000219","31921001"],"pubmed_authors":["Shen L","Fan W","Jin W","Li J","Guo Y","He G","Han X","Zhang W","Li Y","Yang Y","Zhang Z","Wang Y","Yang S"],"additional_accession":[]},"is_claimable":false,"name":"Phosphatidic acid-regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress.","description":"The maintenance of sodium/potassium (Na<sup>+</sup> /K<sup>+</sup> ) homeostasis in plant cells is essential for salt tolerance. Plants export excess Na<sup>+</sup> out of cells mainly through the Salt Overly Sensitive (SOS) pathway, activated by a calcium signal; however, it is unknown whether other signals regulate the SOS pathway and how K<sup>+</sup> uptake is regulated under salt stress. Phosphatidic acid (PA) is emerging as a lipid signaling molecule that modulates cellular processes in development and the response to stimuli. Here, we show that PA binds to the residue Lys57 in SOS2, a core member of the SOS pathway, under salt stress, promoting the activity and plasma membrane localization of SOS2, which activates the Na<sup>+</sup> /H<sup>+</sup> antiporter SOS1 to promote the Na<s","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-07-14T16:26:43.989Z","creation":"2025-04-05T00:30:10.922Z"},"accession":"S-EPMC10106984","cross_references":{"pubmed":["36811145"],"doi":["10.15252/embj.2022112401"]}}