biostudies-literatureUnknown11Roma ASA challenging case of infective endocarditis in a young woman with repaired tetralogy of Fallot and a diagnosis of ankylosing spondylitis is described. Despite the presence of multiple confounding factors, a multidisciplinary approach with the use of multimodality cardiac imaging allowed a correct diagnosis and effective medical treatment. (<b>Level of Difficulty: Intermediate.</b>).JACC. Case reports101798https://www.ebi.ac.uk/biostudies/studies/S-EPMC10107041biostudies-literatureInfective Endocarditis in Adults With Congenital Heart Disease: Never Stop Digging-The Role of Multimodality Imaging.PMC10107041D'Arienzo DDe Rimini MLRoma ASFusco FSarubbi BScognamiglio GfalseInfective Endocarditis in Adults With Congenital Heart Disease: Never Stop Digging-The Role of Multimodality Imaging.A challenging case of infective endocarditis in a young woman with repaired tetralogy of Fallot and a diagnosis of ankylosing spondylitis is described. Despite the presence of multiple confounding factors, a multidisciplinary approach with the use of multimodality cardiac imaging allowed a correct diagnosis and effective medical treatment. (<b>Level of Difficulty: Intermediate.</b>).2023-01-01T00:00:00Z2023 Apr2025-04-18T14:52:41.408Z2025-04-07T01:11:38.404ZS-EPMC101070413707744110.1016/j.jaccas.2023.101798