{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["64(2)"],"submitter":["French J"],"funding":["Engage Therapeutics Inc."],"pubmed_abstract":["<h4>Objective</h4>Alprazolam administered via the Staccato® breath-actuated device is delivered into the deep lung for rapid systemic exposure and is a potential therapy for rapid epileptic seizure termination (REST). We conducted an inpatient study (ENGAGE-E-001 [NCT03478982]) in patients with stereotypic seizure episodes with prolonged or repetitive seizures to determine whether Staccato alprazolam rapidly terminates seizures in a small observed population after administration under direct supervision.<h4>Methods</h4>Adult patients with established diagnosis of focal and/or generalized epilepsy with a documented history of seizure episodes with a predictable pattern were enrolled. They were randomized 1:1:1 to double-blind treatment of a single seizure event with one dose of Staccato alp"],"journal":["Epilepsia"],"pagination":["374-385"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10107237"],"repository":["biostudies-literature"],"pubmed_title":["A randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination."],"pmcid":["PMC10107237"],"pubmed_authors":["Detyniecki K","Dave H","Reich B","DiVentura B","O'Brien TJ","Sadek A","French J","Isojarvi J","Biton V","Liow K","Gong H","Gelfand MA"],"additional_accession":[]},"is_claimable":false,"name":"A randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination.","description":"<h4>Objective</h4>Alprazolam administered via the Staccato® breath-actuated device is delivered into the deep lung for rapid systemic exposure and is a potential therapy for rapid epileptic seizure termination (REST). We conducted an inpatient study (ENGAGE-E-001 [NCT03478982]) in patients with stereotypic seizure episodes with prolonged or repetitive seizures to determine whether Staccato alprazolam rapidly terminates seizures in a small observed population after administration under direct supervision.<h4>Methods</h4>Adult patients with established diagnosis of focal and/or generalized epilepsy with a documented history of seizure episodes with a predictable pattern were enrolled. They were randomized 1:1:1 to double-blind treatment of a single seizure event with one dose of Staccato alp","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-07-14T20:16:23.469Z","creation":"2025-04-04T07:11:19.004Z"},"accession":"S-EPMC10107237","cross_references":{"pubmed":["36268811"],"doi":["10.1111/epi.17441"]}}