biostudies-literatureUnknown64(2)French JEngage Therapeutics Inc.<h4>Objective</h4>Alprazolam administered via the Staccato® breath-actuated device is delivered into the deep lung for rapid systemic exposure and is a potential therapy for rapid epileptic seizure termination (REST). We conducted an inpatient study (ENGAGE-E-001 [NCT03478982]) in patients with stereotypic seizure episodes with prolonged or repetitive seizures to determine whether Staccato alprazolam rapidly terminates seizures in a small observed population after administration under direct supervision.<h4>Methods</h4>Adult patients with established diagnosis of focal and/or generalized epilepsy with a documented history of seizure episodes with a predictable pattern were enrolled. They were randomized 1:1:1 to double-blind treatment of a single seizure event with one dose of Staccato alpEpilepsia374-385https://www.ebi.ac.uk/biostudies/studies/S-EPMC10107237biostudies-literatureA randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination.PMC10107237Detyniecki KDave HReich BDiVentura BO'Brien TJSadek AFrench JIsojarvi JBiton VLiow KGong HGelfand MAfalseA randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination.<h4>Objective</h4>Alprazolam administered via the Staccato® breath-actuated device is delivered into the deep lung for rapid systemic exposure and is a potential therapy for rapid epileptic seizure termination (REST). We conducted an inpatient study (ENGAGE-E-001 [NCT03478982]) in patients with stereotypic seizure episodes with prolonged or repetitive seizures to determine whether Staccato alprazolam rapidly terminates seizures in a small observed population after administration under direct supervision.<h4>Methods</h4>Adult patients with established diagnosis of focal and/or generalized epilepsy with a documented history of seizure episodes with a predictable pattern were enrolled. They were randomized 1:1:1 to double-blind treatment of a single seizure event with one dose of Staccato alp2023-01-01T00:00:00Z2023 Feb2026-07-14T20:16:23.469Z2025-04-04T07:11:19.004ZS-EPMC101072373626881110.1111/epi.17441