biostudies-literatureParr EBEuropean Society for Clinical Nutrition and Metabolism116-126https://www.ebi.ac.uk/biostudies/studies/S-EPMC10107304biostudies-literatureUnknown31 Suppl 1<h4>Objective</h4>This study aimed to assess the impact of time-restricted eating (TRE) on integrated skeletal muscle myofibrillar protein synthesis (MyoPS) rates in males with overweight/obesity.<h4>Methods</h4>A total of 18 healthy males (age 46 ±  5 years; BMI: 30 ± 2 kg/m² ) completed this exploratory, parallel, randomized dietary intervention after a 3-day lead-in diet. Participants then consumed an isoenergetic diet (protein: ~1.0 g/kg body mass per day) following either TRE (10:00 a.m. to 6:00 p.m.) or an extended eating control (CON; 8:00 a.m. to 8:00 p.m.) protocol for 10 days. Integrated MyoPS rates were measured using deuterated water administration with repeated saliva, blood, and muscle sampling. Secondary measures included continuous glucose monitoring and body comObesity (Silver Spring, Md.)Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates: A randomized control trial.PMC10107304Early Career Fellowship (to IWKK)Radford BEHall RCGoessens JPBWheeler MJSenden JMKouw IWKHawley JAParr EBvan Loon LJCfalseEight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates: A randomized control trial.<h4>Objective</h4>This study aimed to assess the impact of time-restricted eating (TRE) on integrated skeletal muscle myofibrillar protein synthesis (MyoPS) rates in males with overweight/obesity.<h4>Methods</h4>A total of 18 healthy males (age 46 ±  5 years; BMI: 30 ± 2 kg/m² ) completed this exploratory, parallel, randomized dietary intervention after a 3-day lead-in diet. Participants then consumed an isoenergetic diet (protein: ~1.0 g/kg body mass per day) following either TRE (10:00 a.m. to 6:00 p.m.) or an extended eating control (CON; 8:00 a.m. to 8:00 p.m.) protocol for 10 days. Integrated MyoPS rates were measured using deuterated water administration with repeated saliva, blood, and muscle sampling. Secondary measures included continuous glucose monitoring and body com2023-01-01T00:00:00Z2023 Feb2025-04-06T11:23:42.74Z2025-04-06T11:23:42.74ZS-EPMC101073043654633010.1002/oby.23637