biostudies-literatureRodriguez-Calvo JInstituto de Salud Carlos III181-190https://www.ebi.ac.uk/biostudies/studies/S-EPMC10107431biostudies-literatureUnknown61(2)<h4>Objective</h4>To analyze the ability to predict perinatal survival and severe neonatal morbidity of cases with early-onset fetal growth restriction (eoFGR) using maternal variables, ultrasound parameters and angiogenic markers at the time of diagnosis.<h4>Methods</h4>This was a prospective observational study in a cohort of singleton pregnancies with a diagnosis of eoFGR (< 32 weeks of gestation). At diagnosis of eoFGR, complete assessment was performed, including ultrasound examination (anatomy, biometry and Doppler assessment) and maternal serum measurement of the angiogenic biomarkers, soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF). Logistic regression models for the prediction of perinatal survival (in cases diagnosed at < 28 weeks) and severe neonatUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and GynecologyPrediction of perinatal survival in early-onset fetal growth restriction: role of placental growth factor.PMC10107431PI13/02405Herraiz IGalindo AQuezada MSVillalain CGomez-Arriaga PIRodriguez-Calvo JfalsePrediction of perinatal survival in early-onset fetal growth restriction: role of placental growth factor.<h4>Objective</h4>To analyze the ability to predict perinatal survival and severe neonatal morbidity of cases with early-onset fetal growth restriction (eoFGR) using maternal variables, ultrasound parameters and angiogenic markers at the time of diagnosis.<h4>Methods</h4>This was a prospective observational study in a cohort of singleton pregnancies with a diagnosis of eoFGR (< 32 weeks of gestation). At diagnosis of eoFGR, complete assessment was performed, including ultrasound examination (anatomy, biometry and Doppler assessment) and maternal serum measurement of the angiogenic biomarkers, soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF). Logistic regression models for the prediction of perinatal survival (in cases diagnosed at < 28 weeks) and severe neonat2023-01-01T00:00:00Z2023 Feb2025-04-27T02:36:42.461Z2025-04-06T18:38:01.727ZS-EPMC101074313637044710.1002/uog.26116