{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Richards T"],"funding":["Health Technology Assessment Programme","National Institute for Health Research (NIHR)"],"pagination":["320-329"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10107684"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["78(3)"],"pubmed_abstract":["In the intravenous iron therapy to treat iron deficiency anaemia in patients undergoing major abdominal surgery (PREVENTT) trial, the use of intravenous iron did not reduce the need for blood transfusion or reduce patient complications or length of hospital stay. As part of the trial protocol, serum was collected at randomisation and on the day of surgery. These samples were analysed in a central laboratory for markers of iron deficiency. We performed a secondary analysis to explore the potential interactions between pre-operative markers of iron deficiency and intervention status on the trial outcome measures. Absolute iron deficiency was defined as ferritin <30 μg.l<sup>-1</sup> ; functional iron deficiency as ferritin 30-100 μg.l<sup>-1</sup> or transferrin saturation < 20%; and the rem"],"journal":["Anaesthesia"],"pubmed_title":["The association between iron deficiency and outcomes: a secondary analysis of the intravenous iron therapy to treat iron deficiency anaemia in patients undergoing major abdominal surgery (PREVENTT) trial."],"pmcid":["PMC10107684"],"funding_grant_id":["10/104/06"],"pubmed_authors":["Brealey DD","Patel A","Keidan J","Keatley C","Kouthra M","Acheson A","Chinnadurai R","MacDougall I","Otto J","Sproates D","Taylor L","Collier T","Leon J","O'Hare D","Vertue M","Martir G","Brain C","James S","Bracewell A","Murphy GJ","Alexander-Sefre F","Klein AA","Taylor A","Patel M","Wroath B","Batley S","Reyes A","Okello J","Alli A","Walker S","Morrison B","Hammonds F","Kasivisvanathan R","Morrison C","Ritzema J","Thyseen M","Mohammed A","Blightman K","Dickson E","Faulds J","Williams P","Williams S","O'Sullivan S","Townshend P","Bolger C","Potter K","Bradbury A","Birch J","Howard J","Redfearn H","Howard K","Bartlett P","Chattersingh A","Chiam P","Jones C","Fofie J","Albuheissi S","Bird S","Birt C","Horner K","Jenkins S","Kelly J","Jhanji S","Biswell L","Poonawala G","Reeves T","Corbett C","Anker R","Tatham K","Van Loen S","Anker S","Catterall M","Parkinson D","Nasseri M","Eeles A","Klein A","Jose J","Macklin A","Rooms M","Bailes I","Mainali P","Sjorin V","Salmon K","Kotze A","Gabrielle C","McNamara H","Thompson J","Grocott M","Adam C","Horsfield G","Wakatsuki M","Swann S","Carter J","Evans R","Skampardoni S","Evans M","Parker J","PREVENTT trial collaborators","Benson V","Gerstman M","Lewis M","Burley T","Dhesi J","Noble H","Dawson H","Gidda R","Guest W","Keegan A","Ball D","Morby L","Geale R","Bercades G","Wallace D","McNeela F","Mercer L","Swinson R","Keen A","Rayat G","Johnson L","Ma S","Miles LF","Dahly D","Browne J","Mazzola F","Holden A","Scott J","Morris S","Smyth D","Anker SD","Pirie K","Magee D","McCormac R","Sanghera S","McCanny J","Butt G","Officer H","Moss S","Dennis R","Goss V","de Silva S","Jackson Y","Homer A","Verma N","Ralph C","Ashcroft P","Dennis A","Harris C","Chima K","Watts A","Collins H","Pagett K","Stoker A","Redman J","Mallett S","Hardwick J","Collins K","Stoddard E","Yarnold A","Crosbie J","Tantony N","Miles L","Rao Baikady R","Pang CL","Hughes T","Wilson J","Altemimi B","Wilson L","Wilson M","Rogerson A","Jeffrey H","Balint A","Harvie D","Hallett K","Staddon S","O'Hara D","Kegan A","Martin S","Pendry K","Ryu J","Preston S","Trundle S","Hughes C","Kubitzek C","Chan K","Hughes A","Beames S","Murphy G","Edwards M","Sellars A","Davies S","Besser MW","Glass J","Clevenger B","Hough M","Plumb J","Humphreys S","Hegarty A","Horton S","Paoloni C","Penny L","Dawas K","Cartwright B","Pepper J","Rocha M","Gallego L","Thomas A","Thomson C","Flintoff L","Shiridzinomwa C","McLeavy L","Melia K","Buchanan F","Abeysiri S","Gibbs C","Saini R","Melville J","Faulkner M","Fielding J","Casey R","Hopkins P","Chishti A","Hariharan V","Pritchard F","Cross J","Uren S","Thomas V","Baikady RR","Godec T","Chau M","Golder K","Wadams B","Shillito L","Lindsey I","Reynolds T","Adams B","Burnish R","Bali S","Black E","Hammond T","Bush D","Curtis J","Kibutu F","Knight R","Wilson A","Cupitt J","Wilson C","Saha S","Murdoch H","Seaward L","Hornzee G","Van Dyck L","Santipillai J","Hammerton K","Khatri P","Hussain Z","Rey S","Ford S","Kelliher L","Dodd M","Barker D","Dermody S","Ravi R","Partridge J","Jahangir N","Lang A","Greenhalgh M","Coulson S","Richards T","Lowe J","Pope A","Keon-Cohen Z","Crook A","Greig L","Bobruk K","Moriarty C","Braude P","Butcher A","Leggett S","McCretton T","Butcher D","Galat MG","Besser M","Yates D","Ward A","Oats P","Macdougall IC","Pinto L","Unsworth I","Allard S","Tyrell B","Alexander T","Tam DK","Symes R","Finney C","Riozzi P","Bradley-Potts J","Wilcock D","Gipson A","Tomlinson J","Harrison E","Clayton T","Hardy A","Walker A","Elhanash S","Williamson N","Williamson L","Lawrence H","Berresford L","Dobson J","Newsome S","Dushianthan A","Pathmanathan B","Smith L","Ng O","Hannaway C","Akbar F","Colling K","Vimalachandran D","Breaton C","Messer C","Al-Saadi Z","Mellis C","Browne JP","Todman E","O'Mahony M"],"additional_accession":[]},"is_claimable":false,"name":"The association between iron deficiency and outcomes: a secondary analysis of the intravenous iron therapy to treat iron deficiency anaemia in patients undergoing major abdominal surgery (PREVENTT) trial.","description":"In the intravenous iron therapy to treat iron deficiency anaemia in patients undergoing major abdominal surgery (PREVENTT) trial, the use of intravenous iron did not reduce the need for blood transfusion or reduce patient complications or length of hospital stay. As part of the trial protocol, serum was collected at randomisation and on the day of surgery. These samples were analysed in a central laboratory for markers of iron deficiency. We performed a secondary analysis to explore the potential interactions between pre-operative markers of iron deficiency and intervention status on the trial outcome measures. Absolute iron deficiency was defined as ferritin <30 μg.l<sup>-1</sup> ; functional iron deficiency as ferritin 30-100 μg.l<sup>-1</sup> or transferrin saturation < 20%; and the rem","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-26T05:01:45.079Z","creation":"2025-04-06T11:20:32.974Z"},"accession":"S-EPMC10107684","cross_references":{"pubmed":["36477695"],"doi":["10.1111/anae.15926"]}}