{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Saladin L"],"funding":["Agence Nationale de la Recherche"],"pagination":["e202215085"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10107923"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["62(4)"],"pubmed_abstract":["We herein present a new concept to produce dual-color photoconvertible probes based on a mechanism called Directed Photooxidation Induced Conversion (DPIC). As a support of this mechanism, styryl-coumarins (SCs) bearing Aromatic Singlet Oxygen Reactive Moieties (ASORMs) like furan and pyrrole have been synthesized. SCs are bright fluorophores, which undergo a hypsochromic conversion upon visible light irradiation due to directed photooxidation of the ASORM that leads to the disruption of conjugation. SC-P, a yellow emitting probe bearing a pyrrole moiety, converts to a stable blue emitting coumarin with a 68 nm shift allowing the photoconversion and tracking of lipid droplet in live cells. This new approach might pave the way to a new generation of photoconvertible dyes for advanced bioimaging applications."],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Dual-Color Photoconvertible Fluorescent Probes Based on Directed Photooxidation Induced Conversion for Bioimaging."],"pmcid":["PMC10107923"],"funding_grant_id":["ANR-19-CE16-0012","19-CE29-0005-01","ANR-19-HBPR-0003"],"pubmed_authors":["Breton V","Danglot L","Dal Pra O","Saladin L","Didier P","Collot M","Klymchenko AS"],"additional_accession":[]},"is_claimable":false,"name":"Dual-Color Photoconvertible Fluorescent Probes Based on Directed Photooxidation Induced Conversion for Bioimaging.","description":"We herein present a new concept to produce dual-color photoconvertible probes based on a mechanism called Directed Photooxidation Induced Conversion (DPIC). As a support of this mechanism, styryl-coumarins (SCs) bearing Aromatic Singlet Oxygen Reactive Moieties (ASORMs) like furan and pyrrole have been synthesized. SCs are bright fluorophores, which undergo a hypsochromic conversion upon visible light irradiation due to directed photooxidation of the ASORM that leads to the disruption of conjugation. SC-P, a yellow emitting probe bearing a pyrrole moiety, converts to a stable blue emitting coumarin with a 68 nm shift allowing the photoconversion and tracking of lipid droplet in live cells. This new approach might pave the way to a new generation of photoconvertible dyes for advanced bioimaging applications.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-26T04:57:25.962Z","creation":"2025-04-06T11:21:38.864Z"},"accession":"S-EPMC10107923","cross_references":{"pubmed":["36420823"],"doi":["10.1002/anie.202215085"]}}