{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cordova M"],"funding":["Swiss National Science Foundation"],"pagination":["e202216607"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10107932"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["62(8)"],"pubmed_abstract":["The resolution of proton solid-state NMR spectra is usually limited by broadening arising from dipolar interactions between spins. Magic-angle spinning alleviates this broadening by inducing coherent averaging. However, even the highest spinning rates experimentally accessible today are not able to completely remove dipolar interactions. Here, we introduce a deep learning approach to determine pure isotropic proton spectra from a two-dimensional set of magic-angle spinning spectra acquired at different spinning rates. Applying the model to 8 organic solids yields high-resolution <sup>1</sup> H solid-state NMR spectra with isotropic linewidths in the 50-400 Hz range."],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Pure Isotropic Proton NMR Spectra in Solids using Deep Learning."],"pmcid":["PMC10107932"],"funding_grant_id":["200020","212046","NCCR MARVEL","200020_212046"],"pubmed_authors":["Cordova M","Emsley L","Torodii D","Simoes de Almeida B","Moutzouri P"],"additional_accession":[]},"is_claimable":false,"name":"Pure Isotropic Proton NMR Spectra in Solids using Deep Learning.","description":"The resolution of proton solid-state NMR spectra is usually limited by broadening arising from dipolar interactions between spins. Magic-angle spinning alleviates this broadening by inducing coherent averaging. However, even the highest spinning rates experimentally accessible today are not able to completely remove dipolar interactions. Here, we introduce a deep learning approach to determine pure isotropic proton spectra from a two-dimensional set of magic-angle spinning spectra acquired at different spinning rates. Applying the model to 8 organic solids yields high-resolution <sup>1</sup> H solid-state NMR spectra with isotropic linewidths in the 50-400 Hz range.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-07-10T03:08:21.145Z","creation":"2025-04-06T11:21:07.698Z"},"accession":"S-EPMC10107932","cross_references":{"pubmed":["36562545"],"doi":["10.1002/anie.202216607"]}}