{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Clancy U"],"funding":["NHS Health Scotland","Scottish Funding Council","British Heart Foundation","NIA NIH HHS","National Institutes of Health","Stroke Association","Age UK","UK Dementia Research Institute","Fondation Leducq","Medical Research Council","Chief Scientist Office","Biotechnology and Biological Sciences Research Council","Mrs Gladys Row Fogo Charitable Trust"],"pagination":["e5855"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10108049"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(1)"],"pubmed_abstract":["<h4>Background</h4>Neuropsychiatric symptoms could form part of an early cerebral small vessel disease prodrome that is detectable before stroke or dementia onset. We aimed to identify whether apathy, depression, anxiety, and subjective memory complaints associate with longitudinal white matter hyperintensity (WMH) progression.<h4>Methods</h4>Community-dwelling older adults from the observational Lothian Birth Cohort 1936 attended three visits at mean ages 73, 76, and 79 years, repeating MRI, Mini-Mental State Examination, neuropsychiatric (Dimensional Apathy Scale, Hospital Anxiety and Depression Scale), and subjective memory symptoms. We ran regression and mixed-effects models for symptoms and normalised WMH volumes (cube root of WMH:ICV × 10).<h4>Results</h4>At age 73, 76, and 79, m = 672, n = 476, and n = 382 participants attended MRI respectively. Worse apathy at age 79 was associated with WMH volume increase (β = 0.27, p = 0.04) in the preceding 6 years. A 1SD increase in apathy score at age 79 associated with a 0.17 increase in WMH (β = 0.17 normalised WMH percent ICV, p = 0.009). In apathy subscales, executive (β = 0.13, p = 0.05) and emotional (β = 0.13, p = 0.04) scores associated with increasing WMH more than initiation scores (β = 0.11, p = 0.08). Increasing WMH also associated with age (β = 0.40, p = 0.002) but not higher depression (β = -0.01, p = 0.78), anxiety (β = 0.05, p = 0.13) scores, or subjective memory complaints (β = 1.12, p = 0.75).<h4>Conclusions</h4>Apathy independently associates with preceding longitudinal WMH progression, while depression, anxiety, and subjective memory complaints do not. Patients with apathy should be considered for enrolment to small vessel disease trials."],"journal":["International journal of geriatric psychiatry"],"pubmed_title":["Are neuropsychiatric symptoms a marker of small vessel disease progression in older adults? Evidence from the Lothian Birth Cohort 1936."],"pmcid":["PMC10108049"],"funding_grant_id":["PPA2016/03","CAF/18/08","G1001245","UKDRI-4002","MR/R024065/1","RE/18/5/34216","MR/K026992/1","TSA15LECT04","G0701120","R01 AG054628","BB/W008793/1","G0700704","SA PG 19/100068","MR/M013111/1"],"pubmed_authors":["Russ TC","Radakovic R","Chappell FM","Corley J","Maniega SM","Wardlaw JM","Clancy U","Deary IJ","Doubal F","Cox SR","Hernandez MDCV","Bastin ME","Taylor AM"],"additional_accession":[]},"is_claimable":false,"name":"Are neuropsychiatric symptoms a marker of small vessel disease progression in older adults? Evidence from the Lothian Birth Cohort 1936.","description":"<h4>Background</h4>Neuropsychiatric symptoms could form part of an early cerebral small vessel disease prodrome that is detectable before stroke or dementia onset. We aimed to identify whether apathy, depression, anxiety, and subjective memory complaints associate with longitudinal white matter hyperintensity (WMH) progression.<h4>Methods</h4>Community-dwelling older adults from the observational Lothian Birth Cohort 1936 attended three visits at mean ages 73, 76, and 79 years, repeating MRI, Mini-Mental State Examination, neuropsychiatric (Dimensional Apathy Scale, Hospital Anxiety and Depression Scale), and subjective memory symptoms. We ran regression and mixed-effects models for symptoms and normalised WMH volumes (cube root of WMH:ICV × 10).<h4>Results</h4>At age 73, 76, and 79, m = 672, n = 476, and n = 382 participants attended MRI respectively. Worse apathy at age 79 was associated with WMH volume increase (β = 0.27, p = 0.04) in the preceding 6 years. A 1SD increase in apathy score at age 79 associated with a 0.17 increase in WMH (β = 0.17 normalised WMH percent ICV, p = 0.009). In apathy subscales, executive (β = 0.13, p = 0.05) and emotional (β = 0.13, p = 0.04) scores associated with increasing WMH more than initiation scores (β = 0.11, p = 0.08). Increasing WMH also associated with age (β = 0.40, p = 0.002) but not higher depression (β = -0.01, p = 0.78), anxiety (β = 0.05, p = 0.13) scores, or subjective memory complaints (β = 1.12, p = 0.75).<h4>Conclusions</h4>Apathy independently associates with preceding longitudinal WMH progression, while depression, anxiety, and subjective memory complaints do not. Patients with apathy should be considered for enrolment to small vessel disease trials.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T22:59:34.355Z","creation":"2025-04-04T22:59:34.355Z"},"accession":"S-EPMC10108049","cross_references":{"pubmed":["36490272"],"doi":["10.1002/gps.5855"]}}