{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["van Straalen JW"],"funding":["Versus Arthritis","European Union","Manchester Biomedical Research Centre","Centre for Epidemiology Versus Arthritis, University of Manchester"],"pagination":["318-327"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10108055"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["75(2)"],"pubmed_abstract":["Objective
To develop and externally validate a prediction model for new-onset chronic uveitis in children with juvenile idiopathic arthritis (JIA) for clinical application.Methods
Data from the international Pharmachild registry were used to develop a multivariable Cox proportional hazards model. Predictors were selected by backward selection, and missing values were handled by multiple imputation. The model was subsequently validated and recalibrated in 2 inception cohorts: the UK Childhood Arthritis Prospective Study (CAPS) study and the German Inception Cohort of Newly diagnosed patients with juvenile idiopathic arthritis (ICON) study. Model performance was evaluated by calibration plots and C statistics for the 2-, 4-, and 7-year risk of uveitis. A diagram and digital r"],"journal":["Arthritis & rheumatology (Hoboken, N.J.)"],"pubmed_title":["Development and External Validation of a Model Predicting New-Onset Chronic Uveitis at Different Disease Durations in Juvenile Idiopathic Arthritis."],"pmcid":["PMC10108055"],"funding_grant_id":["21754","20542","260353","21755"],"pubmed_authors":["Gallizzi R","Smolewska E","Pastore S","Monkemoller K","Minden K","Emminger W","Kallinich T","McErlane F","Hashkes PJ","Hospach A","Herrera CN","Faugier E","Swart JF","Wedderburn L","Dressler F","Horneff G","Hyrich KL","Kearsley-Fleet L","Olivieri AN","Lamot L","van Straalen JW","Thomson W","Chieng A","Hyrich K","Foell D","Heiligenhaus A","Ciurtin C","Ioannou Y","Klotsche J","Ruperto N","Cleary G","de Roock S","Haas JP","Foeldvari I","Foster H","Baildam E","Weller-Heinemann F","Deschner JK","Consolini R","Wulffraat NM","de Boer JH","Paediatric Rheumatology International Trials Organisation (PRINTO), UK CAPS study, and German ICON study","Windschall D","Davidson J"],"additional_accession":[]},"is_claimable":false,"name":"Development and External Validation of a Model Predicting New-Onset Chronic Uveitis at Different Disease Durations in Juvenile Idiopathic Arthritis.","description":"Objective
To develop and externally validate a prediction model for new-onset chronic uveitis in children with juvenile idiopathic arthritis (JIA) for clinical application.Methods
Data from the international Pharmachild registry were used to develop a multivariable Cox proportional hazards model. Predictors were selected by backward selection, and missing values were handled by multiple imputation. The model was subsequently validated and recalibrated in 2 inception cohorts: the UK Childhood Arthritis Prospective Study (CAPS) study and the German Inception Cohort of Newly diagnosed patients with juvenile idiopathic arthritis (ICON) study. Model performance was evaluated by calibration plots and C statistics for the 2-, 4-, and 7-year risk of uveitis. A diagram and digital r","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-06T11:20:54.843Z","creation":"2025-04-06T11:20:54.843Z"},"accession":"S-EPMC10108055","cross_references":{"pubmed":["36054539"],"doi":["10.1002/art.42329"]}}