{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["43(5)"],"submitter":["Chai YL"],"pubmed_abstract":["Chronic cerebral hypoperfusion (CCH) is postulated to underlie multiple pathophysiological processes in vascular dementia (VaD), including extracellular matrix dysfunction. While several extracellular matrix proteins, namely cyclophilin A (CypA), extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases (matrix metalloproteinases, MMP-2 and -9) have been investigated in acute stroke, their involvement in CCH and VaD remains unclear. In this study, CypA-EMMPRIN-gelatinase proteins were analysed in a clinical cohort of 36 aged, cognitively unimpaired subjects and 48 VaD patients, as well as in a bilateral carotid artery stenosis mouse model of CCH. Lower CypA and higher EMMPRIN levels were found in both VaD serum and CCH mouse brain. Furthermore, gelatinases were differentiall"],"journal":["Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism"],"pagination":["722-735"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10108186"],"repository":["biostudies-literature"],"pubmed_title":["Chronic cerebral hypoperfusion alters the CypA-EMMPRIN-gelatinase pathway: Implications for vascular dementia."],"pmcid":["PMC10108186"],"pubmed_authors":["Selvaraji S","Koo EH","Hilal S","Chen CP","Chai YL","Arumugam TV","Jo DG","Rajeev V","Lai MK","Poh L"],"additional_accession":[]},"is_claimable":false,"name":"Chronic cerebral hypoperfusion alters the CypA-EMMPRIN-gelatinase pathway: Implications for vascular dementia.","description":"Chronic cerebral hypoperfusion (CCH) is postulated to underlie multiple pathophysiological processes in vascular dementia (VaD), including extracellular matrix dysfunction. While several extracellular matrix proteins, namely cyclophilin A (CypA), extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases (matrix metalloproteinases, MMP-2 and -9) have been investigated in acute stroke, their involvement in CCH and VaD remains unclear. In this study, CypA-EMMPRIN-gelatinase proteins were analysed in a clinical cohort of 36 aged, cognitively unimpaired subjects and 48 VaD patients, as well as in a bilateral carotid artery stenosis mouse model of CCH. Lower CypA and higher EMMPRIN levels were found in both VaD serum and CCH mouse brain. Furthermore, gelatinases were differentiall","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-20T00:12:27.105Z","creation":"2025-04-20T00:12:27.105Z"},"accession":"S-EPMC10108186","cross_references":{"pubmed":["36537035"],"doi":["10.1177/0271678X221146401","10.1177/0271678x221146401"]}}