biostudies-literatureRajasilta OAcademy of FinlandVarsinais-Suomen SairaanhoitopiiriSigne ja Ane Gyllenbergin SäätiöJuho Vainion SäätiöJane ja Aatos Erkon SäätiöAlfred Kordelinin SäätiöSigrid Juséliuksen SäätiöMaud Kuistilan MuistosäätiöLinnéa och Josef Carlssons StiftelseSuomalais-Norjalainen Lääketieteen SäätiöMaire Taposen SäätiöSuomen Lääketieteen Säätiö242-257https://www.ebi.ac.uk/biostudies/studies/S-EPMC10108202biostudies-literatureUnknown57(2)Prenatal stress exposure (PSE) has been observed to exert a programming effect on the developing infant brain, possibly with long-lasting consequences on temperament, cognitive functions and the risk for developing psychiatric disorders. Several prior studies have revealed that PSE associates with alterations in neonate functional connectivity in the prefrontal regions and amygdala. In this study, we explored whether maternal psychological symptoms measured during the 24th gestational week had associations with neonate resting-state network metrics. Twenty-one neonates (nine female) underwent resting-state fMRI scanning (mean gestation-corrected age at scan 26.95 days) to assess fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo). The ReHo/fALFF maps wThe European journal of neuroscienceMaternal psychological distress associates with alterations in resting-state low-frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex.PMC10108202NARSAD YI Grant #1956Rajasilta OHakkinen SBjornsdotter MParkkola RKarlsson LScheinin NMLahdesmaki TTuulari JJKarlsson HSaunavaara JLehtola SJfalseMaternal psychological distress associates with alterations in resting-state low-frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex.Prenatal stress exposure (PSE) has been observed to exert a programming effect on the developing infant brain, possibly with long-lasting consequences on temperament, cognitive functions and the risk for developing psychiatric disorders. Several prior studies have revealed that PSE associates with alterations in neonate functional connectivity in the prefrontal regions and amygdala. In this study, we explored whether maternal psychological symptoms measured during the 24th gestational week had associations with neonate resting-state network metrics. Twenty-one neonates (nine female) underwent resting-state fMRI scanning (mean gestation-corrected age at scan 26.95 days) to assess fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo). The ReHo/fALFF maps w2023-01-01T00:00:00Z2023 Jan2025-04-26T05:01:23.376Z2025-04-06T11:20:22.376ZS-EPMC101082023645886710.1111/ejn.15882