{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu X"],"funding":["Natural Science Foundation of Zhejiang Province","National Science Foundation Committee","The National Key Technology Research and Development Programme of China, Grant/Award Number: 2022YFC2704200; Key Research and Development Program of Zhejiang Province"],"pagination":["40-49"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10108211"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["129 Suppl 2"],"pubmed_abstract":["<h4>Objective</h4>The aim was to assess the expression levels of SLC7A11 and GPX4 in relation to platinum resistance and prognosis in patients with epithelial ovarian cancer (EOC).<h4>Design</h4>A retrospective cohort study.<h4>Setting</h4>Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.<h4>Population or sample</h4>We included 192 eligible patients from hospital between January 2002 and December 2018.<h4>Methods</h4>We retrospectively analysed the medical records of patients with EOC. Surgical specimens of EOC were stained for SLC7A11 and GPX4. Survival analysis was performed using the Kaplan-Meier and Cox regression methods.<h4>Main outcome measures</h4>Clinical end points include platinum-free interval (PFI), progression-free survival (PFS) and overall survival "],"journal":["BJOG : an international journal of obstetrics and gynaecology"],"pubmed_title":["High co-expression of SLC7A11 and GPX4 as a predictor of platinum resistance and poor prognosis in patients with epithelial ovarian cancer."],"pmcid":["PMC10108211"],"funding_grant_id":["82103505","2019C03010","82171939","LQ20H300002"],"pubmed_authors":["Fan F","Zhang T","Qin J","Fei W","Shen T","Shen S","Gu J","Cheng X","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"High co-expression of SLC7A11 and GPX4 as a predictor of platinum resistance and poor prognosis in patients with epithelial ovarian cancer.","description":"<h4>Objective</h4>The aim was to assess the expression levels of SLC7A11 and GPX4 in relation to platinum resistance and prognosis in patients with epithelial ovarian cancer (EOC).<h4>Design</h4>A retrospective cohort study.<h4>Setting</h4>Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.<h4>Population or sample</h4>We included 192 eligible patients from hospital between January 2002 and December 2018.<h4>Methods</h4>We retrospectively analysed the medical records of patients with EOC. Surgical specimens of EOC were stained for SLC7A11 and GPX4. Survival analysis was performed using the Kaplan-Meier and Cox regression methods.<h4>Main outcome measures</h4>Clinical end points include platinum-free interval (PFI), progression-free survival (PFS) and overall survival ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-26T05:01:55.366Z","creation":"2025-04-06T11:21:13.528Z"},"accession":"S-EPMC10108211","cross_references":{"pubmed":["36485069"],"doi":["10.1111/1471-0528.17327"]}}