{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Han P"],"funding":["Postdoctoral Research Foundation of China","National Natural Science Foundation of China","Australian Research Council"],"pagination":["e202215201"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10108273"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["62(4)"],"pubmed_abstract":["Selective activation of the C(sp<sup>3</sup> )-H bond is an important process in organic synthesis, where efficiently activating a specific C(sp<sup>3</sup> )-H bond without causing side reactions remains one of chemistry's great challenges. Here we report that illuminated plasmonic silver metal nanoparticles (NPs) can abstract hydrogen from the C(sp<sup>3</sup> )-H bond of the C<sub>α</sub> atom of an alkyl aryl ether β-O-4 linkage. The intense electromagnetic near-field generated at the illuminated plasmonic NPs promotes chemisorption of the β-O-4 compound and the transfer of photo-generated hot electrons from the NPs to the adsorbed molecules leads to hydrogen abstraction and direct cleavage of the unreactive ether C<sub>β</sub> -O bond under moderate reaction conditions (≈90 °C). The p"],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Plasmonic Silver-Nanoparticle-Catalysed Hydrogen Abstraction from the C(sp<sup>3</sup> )-H Bond of the Benzylic C<sub>α</sub> atom for Cleavage of Alkyl Aryl Ether Bonds."],"pmcid":["PMC10108273"],"funding_grant_id":["2019M662760","No. 22002038","DP210103357","DP200102652","DE190101450"],"pubmed_authors":["Bottle SE","Han P","Du A","Mao X","Zhu HY","Sarina S","Waclawik ER","Jin Y","Jia J","Zhao JC"],"additional_accession":[]},"is_claimable":false,"name":"Plasmonic Silver-Nanoparticle-Catalysed Hydrogen Abstraction from the C(sp<sup>3</sup> )-H Bond of the Benzylic C<sub>α</sub> atom for Cleavage of Alkyl Aryl Ether Bonds.","description":"Selective activation of the C(sp<sup>3</sup> )-H bond is an important process in organic synthesis, where efficiently activating a specific C(sp<sup>3</sup> )-H bond without causing side reactions remains one of chemistry's great challenges. Here we report that illuminated plasmonic silver metal nanoparticles (NPs) can abstract hydrogen from the C(sp<sup>3</sup> )-H bond of the C<sub>α</sub> atom of an alkyl aryl ether β-O-4 linkage. The intense electromagnetic near-field generated at the illuminated plasmonic NPs promotes chemisorption of the β-O-4 compound and the transfer of photo-generated hot electrons from the NPs to the adsorbed molecules leads to hydrogen abstraction and direct cleavage of the unreactive ether C<sub>β</sub> -O bond under moderate reaction conditions (≈90 °C). The p","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-26T04:59:12.332Z","creation":"2025-04-06T11:23:05.317Z"},"accession":"S-EPMC10108273","cross_references":{"pubmed":["36450692"],"doi":["10.1002/anie.202215201"]}}