biostudies-literatureYan WNational Natural Science Foundation of Chinae28382https://www.ebi.ac.uk/biostudies/studies/S-EPMC10108296biostudies-literatureUnknown95(1)The human monkeypox has become a public health problem globally. Google Trends Index (GTI) is an indicator of public attention, being potential for infectious disease outbreak surveillance. In this study, we used lag-correlation analysis to evaluate the spearman correlation coefficients between public attention and monkeypox epidemic by -36 to +36 days-lag in top 20 countries with most cumulated cases until September 30, 2022, the meta-analyses were performed to pool the coefficients of countries among all lags. We also constructed vector autoregression model and Granger-causality test to probe the significance of GTI in monkeypox forecasting. The strongest spearman correlation was found at lag +13 day (r = 0.53, 95% confidence interval: 0.371-0.703, p < 0.05). Meta-analysis showed signifiJournal of medical virologyAssociation between public attention and monkeypox epidemic: A global lag-correlation analysis.PMC10108296721220017221154039871934002Liu JLiang WLiu MLiu QWang YYan WDu MQin CfalseAssociation between public attention and monkeypox epidemic: A global lag-correlation analysis.The human monkeypox has become a public health problem globally. Google Trends Index (GTI) is an indicator of public attention, being potential for infectious disease outbreak surveillance. In this study, we used lag-correlation analysis to evaluate the spearman correlation coefficients between public attention and monkeypox epidemic by -36 to +36 days-lag in top 20 countries with most cumulated cases until September 30, 2022, the meta-analyses were performed to pool the coefficients of countries among all lags. We also constructed vector autoregression model and Granger-causality test to probe the significance of GTI in monkeypox forecasting. The strongest spearman correlation was found at lag +13 day (r = 0.53, 95% confidence interval: 0.371-0.703, p < 0.05). Meta-analysis showed signifi2023-01-01T00:00:00Z2023 Jan2025-04-04T22:59:31.952Z2025-04-04T22:59:31.952ZS-EPMC101082963647838110.1002/jmv.28382