biostudies-literatureCampbell HMNHLBI NIH HHS304-310https://www.ebi.ac.uk/biostudies/studies/S-EPMC10108376biostudies-literatureUnknown33(3)<h4>Purpose of review</h4>Atrial fibrillation is a common cardiac arrhythmia with a high morbidity and mortality affecting 34 million worldwide. Current therapies are inadequate and often fail to directly address molecular mechanisms of the disease. In this review, we will provide an overview of recent advances in our understanding of the genetic underpinnings of atrial fibrillation.<h4>Recent findings</h4>Large-scale genetic association studies have more than doubled the number of genetic loci associated with atrial fibrillation during the last year. Studies examining how genes at or near these loci can affect the pathogenesis of atrial fibrillation are ongoing in cellular, animal, and computational models. In addition, several recent clinical studies have also demonstrated that variants at these loci can aid in risk stratification of patients.<h4>Summary</h4>There are now over 30 genetic loci associated with atrial fibrillation. A better understanding of how these loci relate to disease pathogenesis may provide insight into novel therapeutic targets and ultimately lead to improved clinical care.Current opinion in cardiologyGenetics of atrial fibrillation: an update.PMC10108376R01 HL117641R01 HL091947R01 HL118761R01 HL134824R01 HL089598Wehrens XHTCampbell HMfalseGenetics of atrial fibrillation: an update.<h4>Purpose of review</h4>Atrial fibrillation is a common cardiac arrhythmia with a high morbidity and mortality affecting 34 million worldwide. Current therapies are inadequate and often fail to directly address molecular mechanisms of the disease. In this review, we will provide an overview of recent advances in our understanding of the genetic underpinnings of atrial fibrillation.<h4>Recent findings</h4>Large-scale genetic association studies have more than doubled the number of genetic loci associated with atrial fibrillation during the last year. Studies examining how genes at or near these loci can affect the pathogenesis of atrial fibrillation are ongoing in cellular, animal, and computational models. In addition, several recent clinical studies have also demonstrated that variants at these loci can aid in risk stratification of patients.<h4>Summary</h4>There are now over 30 genetic loci associated with atrial fibrillation. A better understanding of how these loci relate to disease pathogenesis may provide insight into novel therapeutic targets and ultimately lead to improved clinical care.2018-01-01T00:00:00Z2018 May2024-11-20T08:02:29.255Z2024-11-20T08:02:29.255ZS-EPMC101083762946126210.1097/hco.000000000000050510.1097/HCO.0000000000000505