biostudies-literatureGirard AJoseph C. EdwardsCanada Research Chair on Women’s Cardiac Valvular HealthMedical Research CouncilCanadian Institutes of HealthQuebec Heart and Lung Instituteoead032https://www.ebi.ac.uk/biostudies/studies/S-EPMC10108885biostudies-literatureUnknown3(2)<h4>Aims</h4>Elevated lipoprotein(a) [Lp(a)] levels are associated with the risk of coronary artery disease (CAD) and calcific aortic valve stenosis (CAVS). Observational studies revealed that Lp(a) and C-reactive protein (CRP) levels, a biomarker of systemic inflammation, may jointly predict CAD risk. Whether Lp(a) and CRP levels also jointly predict CAVS incidence and progression is unknown.<h4>Methods and results</h4>We investigated the association of Lp(a) with CAVS according to CRP levels in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk study (<i>n</i> = 18 226, 406 incident cases) and the UK Biobank (<i>n</i> = 438 260, 4582 incident cases), as well as in the ASTRONOMER study (<i>n</i> = 220), which assessed the haemodynamic progression rate of pre-eEuropean heart journal openImpact of C-reactive protein levels on lipoprotein(a)-associated aortic stenosis incidence and progression.PMC10108885MC_UU_00006/1Boekholdt SMPuri RMathieu PGaillard ETheriault SPaulin ADumesnil JCapoulade RStroes ESGChan KLTam JWClavel MAPibarot PGirard ATsimikas SWareham NJTeo KKCouture CArsenault BJManikpurage HDfalseImpact of C-reactive protein levels on lipoprotein(a)-associated aortic stenosis incidence and progression.<h4>Aims</h4>Elevated lipoprotein(a) [Lp(a)] levels are associated with the risk of coronary artery disease (CAD) and calcific aortic valve stenosis (CAVS). Observational studies revealed that Lp(a) and C-reactive protein (CRP) levels, a biomarker of systemic inflammation, may jointly predict CAD risk. Whether Lp(a) and CRP levels also jointly predict CAVS incidence and progression is unknown.<h4>Methods and results</h4>We investigated the association of Lp(a) with CAVS according to CRP levels in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk study (<i>n</i> = 18 226, 406 incident cases) and the UK Biobank (<i>n</i> = 438 260, 4582 incident cases), as well as in the ASTRONOMER study (<i>n</i> = 220), which assessed the haemodynamic progression rate of pre-e2023-01-01T00:00:00Z2023 Mar2026-05-28T08:06:27.354Z2024-11-20T15:16:49.27ZS-EPMC101088853707758010.1093/ehjopen/oead032