{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Quinn JF"],"funding":["BLRD VA","NIDDK NIH HHS","NIA NIH HHS","NINDS NIH HHS"],"pagination":["105888"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10108899"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["174"],"pubmed_abstract":["Based on previous evidence that the non-steroidal estrogen receptor modulator STX mitigates the effects of neurotoxic Amyloid-β (Aβ) in vitro, we have evaluated its neuroprotective benefits in a mouse model of Alzheimer's disease. Cohorts of 5XFAD mice, which begin to accumulate cerebral Aβ at two months of age, were treated with orally-administered STX starting at 6 months of age for two months. After behavioral testing to evaluate cognitive function, biochemical and immunohistochemical assays were used to analyze key markers of mitochondrial function and synaptic integrity. Oral STX treatment attenuated Aβ-associated mitochondrial toxicity and synaptic toxicity in the brain, as previously documented in cultured neurons. STX also moderately improved spatial memory in 5XFAD mice. In addition, STX reduced markers for reactive astrocytosis and microgliosis surrounding amyloid plaques, and also unexpectedly reduced overall levels of cerebral Aβ in the brain. The neuroprotective effects of STX were more robust in females than in males. These results suggest that STX may have therapeutic potential in Alzheimer's Disease."],"journal":["Neurobiology of disease"],"pubmed_title":["The novel estrogen receptor modulator STX attenuates Amyloid-β neurotoxicity in the 5XFAD mouse model of Alzheimer's disease."],"pmcid":["PMC10108899"],"funding_grant_id":["I01 BX003440","R01 DK068098","R21 AG080057","R56 DK068098","RF1 NS115898"],"pubmed_authors":["Bostick Z","Quinn JF","Gray NE","Brumbach BH","Kulik V","Harris CJ","Hack W","Kelly MJ","Copenhaver PF"],"additional_accession":[]},"is_claimable":false,"name":"The novel estrogen receptor modulator STX attenuates Amyloid-β neurotoxicity in the 5XFAD mouse model of Alzheimer's disease.","description":"Based on previous evidence that the non-steroidal estrogen receptor modulator STX mitigates the effects of neurotoxic Amyloid-β (Aβ) in vitro, we have evaluated its neuroprotective benefits in a mouse model of Alzheimer's disease. Cohorts of 5XFAD mice, which begin to accumulate cerebral Aβ at two months of age, were treated with orally-administered STX starting at 6 months of age for two months. After behavioral testing to evaluate cognitive function, biochemical and immunohistochemical assays were used to analyze key markers of mitochondrial function and synaptic integrity. Oral STX treatment attenuated Aβ-associated mitochondrial toxicity and synaptic toxicity in the brain, as previously documented in cultured neurons. STX also moderately improved spatial memory in 5XFAD mice. In addition, STX reduced markers for reactive astrocytosis and microgliosis surrounding amyloid plaques, and also unexpectedly reduced overall levels of cerebral Aβ in the brain. The neuroprotective effects of STX were more robust in females than in males. These results suggest that STX may have therapeutic potential in Alzheimer's Disease.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T00:36:11.327Z","creation":"2025-04-04T00:36:11.327Z"},"accession":"S-EPMC10108899","cross_references":{"pubmed":["36209948"],"doi":["10.1016/j.nbd.2022.105888"]}}