biostudies-literatureUnknown11Sun R<h4>Objective</h4>Vasovagal syncope (VVS) is the commonest form of syncope, and malignant VVS draws substantial attention due to its life-threatening cardiac asystolic risk. This study aimed to explore the predictive role of a wide panel of clinical indicators for malignant VVS in children, and further to develop a nomogram model.<h4>Methods</h4>This is a retrospective case-control study. VVS is diagnosed based on head-up tilt test (HUTT). STATA software (version 14.0) was used for statistical analysis, and effect sizes are expressed as odds ratio (OR) and 95% confidence interval (CI).<h4>Results</h4>Total 370 children with VVS were analyzed, and of them 16 children had malignant VVS. Sixteen malignant VVS and 64 non-malignant VVS were matched on age and sex by a 1:4 propensity scores matcFrontiers in pediatrics1158537https://www.ebi.ac.uk/biostudies/studies/S-EPMC10109463biostudies-literatureDevelopment of a nomogram model to predict malignant vasovagal syncope in Chinese children.PMC10109463Li XShi LSun RZhang MWang HKang YfalseDevelopment of a nomogram model to predict malignant vasovagal syncope in Chinese children.<h4>Objective</h4>Vasovagal syncope (VVS) is the commonest form of syncope, and malignant VVS draws substantial attention due to its life-threatening cardiac asystolic risk. This study aimed to explore the predictive role of a wide panel of clinical indicators for malignant VVS in children, and further to develop a nomogram model.<h4>Methods</h4>This is a retrospective case-control study. VVS is diagnosed based on head-up tilt test (HUTT). STATA software (version 14.0) was used for statistical analysis, and effect sizes are expressed as odds ratio (OR) and 95% confidence interval (CI).<h4>Results</h4>Total 370 children with VVS were analyzed, and of them 16 children had malignant VVS. Sixteen malignant VVS and 64 non-malignant VVS were matched on age and sex by a 1:4 propensity scores matc2023-01-01T00:00:00Z20232025-04-18T14:52:42.157Z2025-04-07T01:12:13.255ZS-EPMC101094633707733210.3389/fped.2023.1158537