{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Daley MF"],"funding":["Intramural CDC HHS"],"pagination":["37-46"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10109516"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Objective</h4>To assess the association between cumulative aluminum exposure from vaccines before age 24 months and persistent asthma at age 24 to 59 months.<h4>Methods</h4>A retrospective cohort study was conducted in the Vaccine Safety Datalink (VSD). Vaccination histories were used to calculate cumulative vaccine-associated aluminum in milligrams (mg). The persistent asthma definition required one inpatient or 2 outpatient asthma encounters, and ≥2 long-term asthma control medication dispenses. Cox proportional hazard models were used to evaluate the association between aluminum exposure and asthma incidence, stratified by eczema presence/absence. Adjusted hazard ratios (aHR) and 95% confidence intervals (CI) per 1 mg increase in aluminum exposure were calculated, adjusted for birth"],"journal":["Academic pediatrics"],"pubmed_title":["Association Between Aluminum Exposure From Vaccines Before Age 24 Months and Persistent Asthma at Age 24 to 59 Months."],"pmcid":["PMC10109516"],"funding_grant_id":["CC999999"],"pubmed_authors":["Getahun D","Nordin JD","McClure DL","Daley MF","Irving SA","Duffy J","Jackson ML","Kamidani S","Reifler LM","Klein NP","Hambidge SJ","DeStefano F","Glanz JM"],"additional_accession":[]},"is_claimable":false,"name":"Association Between Aluminum Exposure From Vaccines Before Age 24 Months and Persistent Asthma at Age 24 to 59 Months.","description":"<h4>Objective</h4>To assess the association between cumulative aluminum exposure from vaccines before age 24 months and persistent asthma at age 24 to 59 months.<h4>Methods</h4>A retrospective cohort study was conducted in the Vaccine Safety Datalink (VSD). Vaccination histories were used to calculate cumulative vaccine-associated aluminum in milligrams (mg). The persistent asthma definition required one inpatient or 2 outpatient asthma encounters, and ≥2 long-term asthma control medication dispenses. Cox proportional hazard models were used to evaluate the association between aluminum exposure and asthma incidence, stratified by eczema presence/absence. Adjusted hazard ratios (aHR) and 95% confidence intervals (CI) per 1 mg increase in aluminum exposure were calculated, adjusted for birth","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan-Feb","modification":"2025-04-04T03:00:27.313Z","creation":"2025-04-04T03:00:27.313Z"},"accession":"S-EPMC10109516","cross_references":{"pubmed":["36180331"],"doi":["10.1016/j.acap.2022.08.006"]}}