biostudies-literatureDaley MFIntramural CDC HHS37-46https://www.ebi.ac.uk/biostudies/studies/S-EPMC10109516biostudies-literatureUnknown23(1)<h4>Objective</h4>To assess the association between cumulative aluminum exposure from vaccines before age 24 months and persistent asthma at age 24 to 59 months.<h4>Methods</h4>A retrospective cohort study was conducted in the Vaccine Safety Datalink (VSD). Vaccination histories were used to calculate cumulative vaccine-associated aluminum in milligrams (mg). The persistent asthma definition required one inpatient or 2 outpatient asthma encounters, and ≥2 long-term asthma control medication dispenses. Cox proportional hazard models were used to evaluate the association between aluminum exposure and asthma incidence, stratified by eczema presence/absence. Adjusted hazard ratios (aHR) and 95% confidence intervals (CI) per 1 mg increase in aluminum exposure were calculated, adjusted for birthAcademic pediatricsAssociation Between Aluminum Exposure From Vaccines Before Age 24 Months and Persistent Asthma at Age 24 to 59 Months.PMC10109516CC999999Getahun DNordin JDMcClure DLDaley MFIrving SADuffy JJackson MLKamidani SReifler LMKlein NPHambidge SJDeStefano FGlanz JMfalseAssociation Between Aluminum Exposure From Vaccines Before Age 24 Months and Persistent Asthma at Age 24 to 59 Months.<h4>Objective</h4>To assess the association between cumulative aluminum exposure from vaccines before age 24 months and persistent asthma at age 24 to 59 months.<h4>Methods</h4>A retrospective cohort study was conducted in the Vaccine Safety Datalink (VSD). Vaccination histories were used to calculate cumulative vaccine-associated aluminum in milligrams (mg). The persistent asthma definition required one inpatient or 2 outpatient asthma encounters, and ≥2 long-term asthma control medication dispenses. Cox proportional hazard models were used to evaluate the association between aluminum exposure and asthma incidence, stratified by eczema presence/absence. Adjusted hazard ratios (aHR) and 95% confidence intervals (CI) per 1 mg increase in aluminum exposure were calculated, adjusted for birth2023-01-01T00:00:00Z2023 Jan-Feb2025-04-04T03:00:27.313Z2025-04-04T03:00:27.313ZS-EPMC101095163618033110.1016/j.acap.2022.08.006