{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Jung AM"],"funding":["National Institute of Environmental Health Sciences","Federal Emergency Management Agency","Assistance to Firefighters"],"pubmed_abstract":["Excretion of toxicants accumulated from firefighter exposures through breastmilk represents a potential hazard. We investigated if firefighting exposures could increase the concentration of polybrominated diphenyl ethers (PBDEs) and aryl hydrocarbon receptor (AhR) activation in excreted breastmilk. Firefighters and non-firefighters collected breastmilk samples prior to any firefighting responses (baseline) and at 2, 8, 24, 48, and 72 hours after a structural fire (firefighters only). Five PBDE analytes (BDEs 15, 28, 47, 99, and 153) detected in at least 90% of samples were summed for analyses. The AhR in vitro DR CALUX® bioassay assessed the mixture of dioxin-like compounds and toxicity from breastmilk extracts. Baseline PBDEs and AhR response were compared between firefighters and non-fir"],"journal":["Toxicological sciences : an official journal of the Society of Toxicology"],"pagination":["kfad017"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10109531"],"repository":["biostudies-literature"],"pubmed_title":["Excretion of polybrominated diphenyl ethers and AhR activation in breastmilk among firefighters."],"pmcid":["PMC10109531"],"funding_grant_id":["T32 ES007091","EMW-2019-FP-00526","EMW-2015-FP-00848","P30 ES006694"],"pubmed_authors":["White M","Hoppe-Jones C","Littau SR","Burgess JL","Beitel SC","Jung AM","Billheimer D","Gutenkunst SL","Jahnke SA","Cherrington N"],"additional_accession":[]},"is_claimable":false,"name":"Excretion of polybrominated diphenyl ethers and AhR activation in breastmilk among firefighters.","description":"Excretion of toxicants accumulated from firefighter exposures through breastmilk represents a potential hazard. We investigated if firefighting exposures could increase the concentration of polybrominated diphenyl ethers (PBDEs) and aryl hydrocarbon receptor (AhR) activation in excreted breastmilk. Firefighters and non-firefighters collected breastmilk samples prior to any firefighting responses (baseline) and at 2, 8, 24, 48, and 72 hours after a structural fire (firefighters only). Five PBDE analytes (BDEs 15, 28, 47, 99, and 153) detected in at least 90% of samples were summed for analyses. The AhR in vitro DR CALUX® bioassay assessed the mixture of dioxin-like compounds and toxicity from breastmilk extracts. Baseline PBDEs and AhR response were compared between firefighters and non-fir","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-05-18T11:12:28.453Z","creation":"2025-05-18T11:12:28.453Z"},"accession":"S-EPMC10109531","cross_references":{"pubmed":["36856729"],"doi":["10.1093/toxsci/kfad017"]}}