biostudies-literatureDing TShanghai Jiao Tong University1104255https://www.ebi.ac.uk/biostudies/studies/S-EPMC10111053biostudies-literatureUnknown10<h4>Background</h4>Some studies have shown that a pro-inflammatory diet may be associated with cognitive function, but their conclusions have varied considerably. We here present a meta-analysis of the current published literature on DII score and its association with cognitive health.<h4>Methods</h4>In this meta-analysis, the PubMed, Embase, Web of Science, and Cochrane databases were searched in September 2022. The reported indexes, specifically OR, RR, and β, were extracted and analyzed using R version 3.1.0.<h4>Results</h4>A total of 636 studies in databases were identified, and 12 were included in the meta-analysis. Higher DII was associated with an increased risk of AD and MCI (OR = 1.34; 95% CI = 1.21-1.49). Meanwhile, it may also cause global function impairment (categorical: OR = Frontiers in nutritionMeta-analysis of the association between dietary inflammatory index and cognitive health.PMC101110532020YJZX0139YG2022QN011Lu MShen JDing TAimaiti MCui SBian DWang LfalseMeta-analysis of the association between dietary inflammatory index and cognitive health.<h4>Background</h4>Some studies have shown that a pro-inflammatory diet may be associated with cognitive function, but their conclusions have varied considerably. We here present a meta-analysis of the current published literature on DII score and its association with cognitive health.<h4>Methods</h4>In this meta-analysis, the PubMed, Embase, Web of Science, and Cochrane databases were searched in September 2022. The reported indexes, specifically OR, RR, and β, were extracted and analyzed using R version 3.1.0.<h4>Results</h4>A total of 636 studies in databases were identified, and 12 were included in the meta-analysis. Higher DII was associated with an increased risk of AD and MCI (OR = 1.34; 95% CI = 1.21-1.49). Meanwhile, it may also cause global function impairment (categorical: OR = 2023-01-01T00:00:00Z20232025-04-19T19:40:32.419Z2025-04-19T19:40:32.419ZS-EPMC101110533708191710.3389/fnut.2023.1104255