{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["D'Agosto S"],"pubmed_abstract":["Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare and highly heterogeneous neoplasms whose incidence has markedly increased over the last decades. A grading system based on the tumor cells' proliferation index predicts high-risk for G3 NETs. However, low-to-intermediate grade (G1/G2) NETs have an unpredictable clinical course that varies from indolent to highly malignant. Cultures of human cancer cells enable to perform functional perturbation analyses that are instrumental to enhance our understanding of cancer biology. To date, no tractable and reliable long-term culture of G1/G2 NET has been reported to permit disease modeling and pharmacological screens. Here, we report of the first long-term culture of a G2 metastatic small intestinal NET that preserves the main genetic"],"journal":["Frontiers in endocrinology"],"pagination":["999792"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10112019"],"repository":["biostudies-literature"],"pubmed_title":["Long-term organoid culture of a small intestinal neuroendocrine tumor."],"pmcid":["PMC10112019"],"pubmed_authors":["Bassi C","Simbolo M","Andreani S","D'Agosto S","Pezzini F","Rusev B","Corbo V","Fiorini E","Landoni L","Luchini C","Delfino P","Lawlor RT","Capelli P","Vicentini C","Scarpa A","Pea A"],"additional_accession":[]},"is_claimable":false,"name":"Long-term organoid culture of a small intestinal neuroendocrine tumor.","description":"Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare and highly heterogeneous neoplasms whose incidence has markedly increased over the last decades. A grading system based on the tumor cells' proliferation index predicts high-risk for G3 NETs. However, low-to-intermediate grade (G1/G2) NETs have an unpredictable clinical course that varies from indolent to highly malignant. Cultures of human cancer cells enable to perform functional perturbation analyses that are instrumental to enhance our understanding of cancer biology. To date, no tractable and reliable long-term culture of G1/G2 NET has been reported to permit disease modeling and pharmacological screens. Here, we report of the first long-term culture of a G2 metastatic small intestinal NET that preserves the main genetic","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-05-14T03:14:45.751Z","creation":"2024-12-03T15:59:27.763Z"},"accession":"S-EPMC10112019","cross_references":{"pubmed":["37082125"],"doi":["10.3389/fendo.2023.999792"]}}